Reviewed, UniProtKB/Swiss-Prot Q7N6J4 (URK_PHOLL)

Names and origin

Protein names

Recommended name:
    Uridine kinase
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase
    Cytidine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	plu1556

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine salvage Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Uridine kinase HAMAP MF_00551		PRO_1000017886
Regions
	Nucleotide binding	15 – 22	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7N6J4-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 9A8C028E7D5871F3	FASTA	213	24,488
	10 20 30 40 50 60 MADEAYQCTI VGISGASASG KSLIANTLYR ELRAQVGDHN IGIIPEDCYY KDQSDLSMEE 70 80 90 100 110 120 RYKTNYDHPS SMDHNLLFSH LQALKMGESI ELPQYDYVAH TRKPEAIHFA PKRVIILEGI 130 140 150 160 170 180 LLLTDKRLRQ EMDFSIFVDT PLDICLMRRI KRDVHERGRS LDSVIEQYHK TVRPMFLQFI 190 200 210 EPSKQYADII VPRGGKNRVA IDILKAKIGQ FCE

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571864 Genomic DNA. Translation: CAE13849.1.
RefSeq	NP_928847.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2801551.
GenomeReviews	Gene locus plu1556 in contig BX470251_GR.
KEGG	plu:plu1556.
NMPDR	fig|243265.1.peg.1471.
Organism-specific databases
PhotoList	plu1556.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7N6J4.
OMA	Q7N6J4. NQFIEPT.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU1556-MON.
BRENDA	2.7.1.48. 308689.
Family and domain databases
HAMAP	MF_00551. [Tree]
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_PHOLL

Accession

Primary (citable) accession number: Q7N6J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)