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Q7N6I1

- HIS8_PHOLL

UniProt

Q7N6I1 - HIS8_PHOLL

Protein

Putative histidine biosynthesis bifunctional protein HisCD

Gene

hisCD

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity
    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi261 – 2611ZincBy similarity
    Metal bindingi264 – 2641ZincBy similarity
    Active sitei328 – 3281By similarity
    Active sitei329 – 3291By similarity
    Metal bindingi362 – 3621ZincBy similarity
    Metal bindingi421 – 4211ZincBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. histidinol-phosphate transaminase activity Source: UniProtKB-EC
    3. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro
    5. pyridoxal phosphate binding Source: InterPro
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Oxidoreductase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Pyridoxal phosphate, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00012.
    UPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative histidine biosynthesis bifunctional protein HisCD
    Including the following 2 domains:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Histidinol-phosphate aminotransferase (EC:2.6.1.9)
    Alternative name(s):
    Imidazole acetol-phosphate transaminase
    Gene namesi
    Name:hisCD
    Synonyms:hisD
    Ordered Locus Names:plu1569
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu1569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 807807Putative histidine biosynthesis bifunctional protein HisCDPRO_0000153415Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei655 – 6551N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ7N6I1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi243265.plu1569.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N6I1.
    SMRiQ7N6I1. Positions 5-432, 450-794.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 440440Histidinol dehydrogenaseAdd
    BLAST
    Regioni441 – 807367Histidinol-phosphate aminotransferaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0079.
    KOiK00013.
    OMAiSSEWITA.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01023. HisC_aminotrans_2.
    MF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    SSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01141. hisC. 1 hit.
    TIGR00069. hisD. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7N6I1-1 [UniParc]FASTAAdd to Basket

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    MTDHFDTLIR WQECHDEQQN ALLTRPAISA SVEISRTVEQ ILHAVKEYGD    50
    HTLREFSRRF DKTVIENIRI SPEEIAAAEN SLNNDIKQAM QQAMNNIRVF 100
    HEAQKPIKIE VETQPGVYCQ QVTRPIDSVG LYIPGGSAPL LSTVLMLGTP 150
    AQIAGCHKVV LCSPPPIANE ILYAATLCGI TEIFQIGGAQ AIAAMAFGTE 200
    SVPKVDKIFG PGNAYVTEAK RQVSQRVDGA TIDMPAGPSE LLIIADAGAN 250
    PVFVAADLLS QAEHGPDSQV ILVTPDEALA KKVITEIEKQ LTRLPRNQIA 300
    AKALAHSRII VTTSLQQCVE ISNRYGPEHL IIQTRQPEQL VEKITSAGSV 350
    FLGDWSPESA GDYASGTNHV LPTYGYTSTY SSLGLADFLK RMTIQQLTPQ 400
    GLLNLSQTIE TLAQAEQLTA HKNALTLRVA ALNIAGQGVN MNNIFDANLL 450
    ARENIRKLTP YMSARRLGGK GDVWLNANEY PLAPDFQCTE QTLNRYPDCQ 500
    PASVIRRYAA YAGLQPEQVL ACRGADESIE LLIRVFCEPG QDVVLFCPPT 550
    YGMYSVSAET FGVEQKKITA LENWQLDIEA IENNLDRVKL IYICSPNNPT 600
    GNAINPDSLR KILELTANRA IVTIDEAYIE FCPENSIASW LKNYPNLVIL 650
    RTLSKAFALA GLRCGFTLAS VDIITLLLKV IAPYPLSTPV ADIAAQALTA 700
    ENIAIMQKRV VEIRENRNDL QQALNKLAIV EKVFPSETNY ILVKFYDAET 750
    VFKTLWHQGI ILRDQRKQPG LEGCLRITIG SRKECERVVE AISALSTVNE 800
    QPKEIAN 807
    Length:807
    Mass (Da):88,850
    Last modified:December 15, 2003 - v1
    Checksum:i648F98DD2F9F706E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571864 Genomic DNA. Translation: CAE13862.1.
    RefSeqiNP_928860.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE13862; CAE13862; plu1569.
    GeneIDi2801564.
    KEGGiplu:plu1569.
    PATRICi20507017. VBIPhoLum48522_1751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571864 Genomic DNA. Translation: CAE13862.1 .
    RefSeqi NP_928860.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N6I1.
    SMRi Q7N6I1. Positions 5-432, 450-794.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu1569.

    Proteomic databases

    PRIDEi Q7N6I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE13862 ; CAE13862 ; plu1569 .
    GeneIDi 2801564.
    KEGGi plu:plu1569.
    PATRICi 20507017. VBIPhoLum48522_1751.

    Organism-specific databases

    GenoListi plu1569.

    Phylogenomic databases

    eggNOGi COG0079.
    KOi K00013.
    OMAi SSEWITA.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00012 .
    UPA00031 ; UER00014 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01023. HisC_aminotrans_2.
    MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01141. hisC. 1 hit.
    TIGR00069. hisD. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiHIS8_PHOLL
    AccessioniPrimary (citable) accession number: Q7N6I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3