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Q7N6I1

- HIS8_PHOLL

UniProt

Q7N6I1 - HIS8_PHOLL

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Protein

Putative histidine biosynthesis bifunctional protein HisCD

Gene
hisCD, hisD, plu1569
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation
L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi261 – 2611Zinc By similarity
Metal bindingi264 – 2641Zinc By similarity
Active sitei328 – 3281 By similarity
Active sitei329 – 3291 By similarity
Metal bindingi362 – 3621Zinc By similarity
Metal bindingi421 – 4211Zinc By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-EC
  2. histidinol-phosphate transaminase activity Source: UniProtKB-EC
  3. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  4. NAD binding Source: InterPro
  5. pyridoxal phosphate binding Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Oxidoreductase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Pyridoxal phosphate, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.
UPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histidine biosynthesis bifunctional protein HisCD
Including the following 2 domains:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisCD
Synonyms:hisD
Ordered Locus Names:plu1569
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu1569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Putative histidine biosynthesis bifunctional protein HisCDUniRule annotationPRO_0000153415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei655 – 6551N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ7N6I1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu1569.

Structurei

3D structure databases

ProteinModelPortaliQ7N6I1.
SMRiQ7N6I1. Positions 5-432, 450-794.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 440440Histidinol dehydrogenaseUniRule annotationAdd
BLAST
Regioni441 – 807367Histidinol-phosphate aminotransferaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the histidinol dehydrogenase family.

Phylogenomic databases

eggNOGiCOG0079.
KOiK00013.
OMAiSSEWITA.
OrthoDBiEOG6CVVCR.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2.
MF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
TIGR00069. hisD. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N6I1-1 [UniParc]FASTAAdd to Basket

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MTDHFDTLIR WQECHDEQQN ALLTRPAISA SVEISRTVEQ ILHAVKEYGD    50
HTLREFSRRF DKTVIENIRI SPEEIAAAEN SLNNDIKQAM QQAMNNIRVF 100
HEAQKPIKIE VETQPGVYCQ QVTRPIDSVG LYIPGGSAPL LSTVLMLGTP 150
AQIAGCHKVV LCSPPPIANE ILYAATLCGI TEIFQIGGAQ AIAAMAFGTE 200
SVPKVDKIFG PGNAYVTEAK RQVSQRVDGA TIDMPAGPSE LLIIADAGAN 250
PVFVAADLLS QAEHGPDSQV ILVTPDEALA KKVITEIEKQ LTRLPRNQIA 300
AKALAHSRII VTTSLQQCVE ISNRYGPEHL IIQTRQPEQL VEKITSAGSV 350
FLGDWSPESA GDYASGTNHV LPTYGYTSTY SSLGLADFLK RMTIQQLTPQ 400
GLLNLSQTIE TLAQAEQLTA HKNALTLRVA ALNIAGQGVN MNNIFDANLL 450
ARENIRKLTP YMSARRLGGK GDVWLNANEY PLAPDFQCTE QTLNRYPDCQ 500
PASVIRRYAA YAGLQPEQVL ACRGADESIE LLIRVFCEPG QDVVLFCPPT 550
YGMYSVSAET FGVEQKKITA LENWQLDIEA IENNLDRVKL IYICSPNNPT 600
GNAINPDSLR KILELTANRA IVTIDEAYIE FCPENSIASW LKNYPNLVIL 650
RTLSKAFALA GLRCGFTLAS VDIITLLLKV IAPYPLSTPV ADIAAQALTA 700
ENIAIMQKRV VEIRENRNDL QQALNKLAIV EKVFPSETNY ILVKFYDAET 750
VFKTLWHQGI ILRDQRKQPG LEGCLRITIG SRKECERVVE AISALSTVNE 800
QPKEIAN 807
Length:807
Mass (Da):88,850
Last modified:December 15, 2003 - v1
Checksum:i648F98DD2F9F706E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571864 Genomic DNA. Translation: CAE13862.1.
RefSeqiNP_928860.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE13862; CAE13862; plu1569.
GeneIDi2801564.
KEGGiplu:plu1569.
PATRICi20507017. VBIPhoLum48522_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571864 Genomic DNA. Translation: CAE13862.1 .
RefSeqi NP_928860.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N6I1.
SMRi Q7N6I1. Positions 5-432, 450-794.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu1569.

Proteomic databases

PRIDEi Q7N6I1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE13862 ; CAE13862 ; plu1569 .
GeneIDi 2801564.
KEGGi plu:plu1569.
PATRICi 20507017. VBIPhoLum48522_1751.

Organism-specific databases

GenoListi plu1569.

Phylogenomic databases

eggNOGi COG0079.
KOi K00013.
OMAi SSEWITA.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00012 .
UPA00031 ; UER00014 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01023. HisC_aminotrans_2.
MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53383. SSF53383. 1 hit.
SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01141. hisC. 1 hit.
TIGR00069. hisD. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiHIS8_PHOLL
AccessioniPrimary (citable) accession number: Q7N6I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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