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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:plu1630
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

Subcellular locationi

Q7N6C6:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 162HelicalUniRule annotationAdd BLAST20
Transmembranei166 – 185HelicalUniRule annotationAdd BLAST20
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei274 – 294HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925921 – 581Lipid A export ATP-binding/permease protein MsbAAdd BLAST581

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu1630.

Structurei

3D structure databases

ProteinModelPortaliQ7N6C6.
SMRiQ7N6C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 309ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini341 – 577ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N6C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDKDLSTWQ TFCRLWPIVS PFRIGLIVAA VALILNAAGD TLMLSLLKPL
60 70 80 90 100
LDEGFGKASS DVLKWMPLIV IALMIMRGLS GFVSSYCISW VSGKVVMQMR
110 120 130 140 150
RRLFSHMMGM PVSFFDQQST GTLLSRITYD SEQVASSSSS ALITVVREGA
160 170 180 190 200
SIIGLFVLMF YYSWQLSLIL IVIAPIVSLV IRVVSKRFRS ISKNMQNSMG
210 220 230 240 250
QVTASAEQML KGHKEVLIFG GQNVETERFN KVSNHMRQQG MKMVSASSIS
260 270 280 290 300
DPIIQLIASF ALAFVLYAAS FPDIMETLTA GKITVVFSSM IALMRPLKSL
310 320 330 340 350
TNVNAQFQRG MAACQTLFSI LDMEQEKDDG KLELKKANGD IEFRNVTFCY
360 370 380 390 400
PTKELPALQN ISMYIPAGKI VALVGRSGSG KSTIANLLTR FYDVNEGNIF
410 420 430 440 450
LDGHDLREYK LSSLRGQVAL VSQNVHLFND TVANNIAYAS ENRYSREEIE
460 470 480 490 500
KAAEMAYAMD FIRKLDNGLD TMIGENGVLL SGGQRQRIAI ARALLRDSPV
510 520 530 540 550
LILDEATSAL DTESERAIQA ALDELQKNRT SLVIAHRLST IENADEILVV
560 570 580
EDGHIVERGD HLSLLERNGV YSQLHRMQFG Q
Length:581
Mass (Da):64,446
Last modified:December 15, 2003 - v1
Checksum:i98FDA624594A3F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571864 Genomic DNA. Translation: CAE13923.1.

Genome annotation databases

EnsemblBacteriaiCAE13923; CAE13923; plu1630.
KEGGiplu:plu1630.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PHOLL
AccessioniPrimary (citable) accession number: Q7N6C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families