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Protein

Acyl-CoA reductase

Gene

luxC

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.By similarity

Catalytic activityi

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Luminescence

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00569.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA reductase (EC:1.2.1.50)
Gene namesi
Name:luxC
Ordered Locus Names:plu2079
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514 Componenti: Chromosome

Organism-specific databases

GenoListiplu2079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Acyl-CoA reductasePRO_0000220198Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243265.plu2079.

Structurei

3D structure databases

ProteinModelPortaliQ7N577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxC family.Curated

Phylogenomic databases

eggNOGiNOG15417.
HOGENOMiHOG000005461.
KOiK03400.
OMAiTVGQRWK.
OrthoDBiEOG6WQD3S.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKISFIIN GQVEIFPESD DLVQSINFGD NSVYLPILNN SHVKNIIDYN
60 70 80 90 100
ENNKLRLHNI VNFLYTVGQR WKNEEYSRRR TYIRDLKKYM GYSEAMAKLE
110 120 130 140 150
ANWISMILCS KGGLYDVVEN ELGSRHIMDE WLPQDESYIK AFPKGKSIHL
160 170 180 190 200
LAGNVPLSGI MSILRAILTK NQCIIKTSST DPFTANALAL SFIDVDPNHP
210 220 230 240 250
ITRSLSVVYW PHQGDTSLAK EIMQHMDVIV AWGGEDAINW AVEHAPPYAD
260 270 280 290 300
VIKFGSKKSF CIIDNPVDLT SAATGAAHDI CFYDQRACFS AQNIYYMGNQ
310 320 330 340 350
YEEFKLALIE KLNLYAHILP NAKKDFDEKA AYSLVQKESL FAGLKVEVDV
360 370 380 390 400
HQRWMIIESN AGVEFNQPLG RCVYLHHVDN IEQVLPYVQK NKTQTISIFP
410 420 430 440 450
WESAFKYRDA LALRGAERIV EAGMNNIFRV GGSHDGMRPL QRLVTYISHE
460 470 480
RPSHYTAKDV AVEIEQTRFL EEDKFLVFVP
Length:480
Mass (Da):54,815
Last modified:December 15, 2003 - v1
Checksum:i48DC9106D75662BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571866 Genomic DNA. Translation: CAE14372.1.
RefSeqiNP_929340.1. NC_005126.1.
WP_011146334.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE14372; CAE14372; plu2079.
KEGGiplu:plu2079.
PATRICi20508221. VBIPhoLum48522_2348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571866 Genomic DNA. Translation: CAE14372.1.
RefSeqiNP_929340.1. NC_005126.1.
WP_011146334.1. NC_005126.1.

3D structure databases

ProteinModelPortaliQ7N577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu2079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE14372; CAE14372; plu2079.
KEGGiplu:plu2079.
PATRICi20508221. VBIPhoLum48522_2348.

Organism-specific databases

GenoListiplu2079.

Phylogenomic databases

eggNOGiNOG15417.
HOGENOMiHOG000005461.
KOiK03400.
OMAiTVGQRWK.
OrthoDBiEOG6WQD3S.

Enzyme and pathway databases

UniPathwayiUPA00569.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiLUXC_PHOLL
AccessioniPrimary (citable) accession number: Q7N577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.