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Protein

Pseudouridine-5'-phosphate glycosidase 1

Gene

psuG1

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.UniRule annotation

Catalytic activityi

Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei29 – 291Proton donorUniRule annotation
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei110 – 1101Substrate; via amide nitrogenUniRule annotation
Metal bindingi142 – 1421ManganeseUniRule annotation
Active sitei163 – 1631NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphate glycosidase 1UniRule annotation (EC:4.2.1.70UniRule annotation)
Short name:
PsiMP glycosidase 1UniRule annotation
Gene namesi
Name:psuG1UniRule annotation
Ordered Locus Names:plu2187
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Pseudouridine-5'-phosphate glycosidase 1PRO_0000390535Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu2187.

Structurei

3D structure databases

ProteinModelPortaliQ7N4X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1463Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the pseudouridine-5'-phosphate glycosidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D53. Bacteria.
COG2313. LUCA.
HOGENOMiHOG000064311.
KOiK16329.
OMAiKAIEINW.
OrthoDBiPOG091H08AG.

Family and domain databases

HAMAPiMF_01876. PsiMP_glycosidase. 1 hit.
InterProiIPR007342. PsuG.
[Graphical view]
PANTHERiPTHR10584:SF1. PTHR10584:SF1. 1 hit.
PfamiPF04227. Indigoidine_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N4X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISNKVPFK FSLEVKEALE SGKPVVALES NVITHGLDYP DNVTTAKNVE
60 70 80 90 100
QAVRESGAIP ATIGIDKGEF LIGMSDEQIE KFATASHVPK VTSRDIPVVL
110 120 130 140 150
ASGGMGATTV ASSILAAEIA GIKFFCSAGI GGVHRGAETS MDISADLTQL
160 170 180 190 200
TRSRVAVVCA GAKNILDIGL TLEFLETWNV PVISYQSDDF PAFYCRSSGF
210 220 230 240 250
KSPQRLDELA VIAKAIEINW MLPGGKGVLI TTPTKPEDAL DNQKIDIIIQ
260 270 280 290 300
EAVLEAKKKN IVGNSLTKYL MRMVDRETDG ISAKANMAVL VNTAEVAGKL
310
AVAACLQSST FFARIKSQ
Length:318
Mass (Da):33,907
Last modified:December 15, 2003 - v1
Checksum:iC372B44717CD44CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571866 Genomic DNA. Translation: CAE14480.1.
RefSeqiWP_011146441.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE14480; CAE14480; plu2187.
KEGGiplu:plu2187.
PATRICi20508483. VBIPhoLum48522_2480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571866 Genomic DNA. Translation: CAE14480.1.
RefSeqiWP_011146441.1. NC_005126.1.

3D structure databases

ProteinModelPortaliQ7N4X5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu2187.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE14480; CAE14480; plu2187.
KEGGiplu:plu2187.
PATRICi20508483. VBIPhoLum48522_2480.

Phylogenomic databases

eggNOGiENOG4105D53. Bacteria.
COG2313. LUCA.
HOGENOMiHOG000064311.
KOiK16329.
OMAiKAIEINW.
OrthoDBiPOG091H08AG.

Family and domain databases

HAMAPiMF_01876. PsiMP_glycosidase. 1 hit.
InterProiIPR007342. PsuG.
[Graphical view]
PANTHERiPTHR10584:SF1. PTHR10584:SF1. 1 hit.
PfamiPF04227. Indigoidine_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSUG1_PHOLL
AccessioniPrimary (citable) accession number: Q7N4X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.