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Protein

Pseudouridine-5'-phosphate glycosidase 1

Gene

psuG1

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.UniRule annotation

Catalytic activityi

Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei29Proton donorUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei110Substrate; via amide nitrogenUniRule annotation1
Metal bindingi142ManganeseUniRule annotation1
Active sitei163NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciPLUM243265:G1GTE-2236-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphate glycosidase 1UniRule annotation (EC:4.2.1.70UniRule annotation)
Short name:
PsiMP glycosidase 1UniRule annotation
Gene namesi
Name:psuG1UniRule annotation
Ordered Locus Names:plu2187
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003905351 – 318Pseudouridine-5'-phosphate glycosidase 1Add BLAST318

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu2187

Structurei

3D structure databases

ProteinModelPortaliQ7N4X5
SMRiQ7N4X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 146Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the pseudouridine-5'-phosphate glycosidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D53 Bacteria
COG2313 LUCA
HOGENOMiHOG000064311
KOiK16329
OMAiPAFYCRS
OrthoDBiPOG091H08AG

Family and domain databases

Gene3Di3.40.1790.10, 1 hit
HAMAPiMF_01876 PsiMP_glycosidase, 1 hit
InterProiView protein in InterPro
IPR022830 Indigdn_synthA-like
IPR007342 PsuG
PANTHERiPTHR42909 PTHR42909, 1 hit
PfamiView protein in Pfam
PF04227 Indigoidine_A, 1 hit
SUPFAMiSSF110581 SSF110581, 1 hit

Sequencei

Sequence statusi: Complete.

Q7N4X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISNKVPFK FSLEVKEALE SGKPVVALES NVITHGLDYP DNVTTAKNVE
60 70 80 90 100
QAVRESGAIP ATIGIDKGEF LIGMSDEQIE KFATASHVPK VTSRDIPVVL
110 120 130 140 150
ASGGMGATTV ASSILAAEIA GIKFFCSAGI GGVHRGAETS MDISADLTQL
160 170 180 190 200
TRSRVAVVCA GAKNILDIGL TLEFLETWNV PVISYQSDDF PAFYCRSSGF
210 220 230 240 250
KSPQRLDELA VIAKAIEINW MLPGGKGVLI TTPTKPEDAL DNQKIDIIIQ
260 270 280 290 300
EAVLEAKKKN IVGNSLTKYL MRMVDRETDG ISAKANMAVL VNTAEVAGKL
310
AVAACLQSST FFARIKSQ
Length:318
Mass (Da):33,907
Last modified:December 15, 2003 - v1
Checksum:iC372B44717CD44CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571866 Genomic DNA Translation: CAE14480.1
RefSeqiWP_011146441.1, NC_005126.1

Genome annotation databases

EnsemblBacteriaiCAE14480; CAE14480; plu2187
KEGGiplu:plu2187

Similar proteinsi

Entry informationi

Entry nameiPSUG1_PHOLL
AccessioniPrimary (citable) accession number: Q7N4X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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