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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotationImported (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:plu2801Imported
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)Imported
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514 Componenti: Chromosome

Organism-specific databases

GenoListiplu2801.

Interactioni

Protein-protein interaction databases

STRINGi243265.plu2801.

Structurei

3D structure databases

ProteinModelPortaliQ7N3B7.
SMRiQ7N3B7. Positions 1-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N3B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVVIPAE GKKITVDAKG KLVVPNNPVI PYIEGDGIGV DVTPAMLKVV
60 70 80 90 100
DAAVQKAYQG ERKISWMEIY TGEKSTHVYG KDVWLPDETL DLIREYRVAI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYQGTPS PVKQPELTDM
160 170 180 190 200
VIFRENAEDI YAGIEWKAGS VEADKVIKFL QEEMGVNKIR FPQQCGIGVK
210 220 230 240 250
PCSEEGTKRL VRAAIEYAID NDRESVTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGGELLD GGPWVKIKNP KNGKEIIVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ACMNLNGDYI SDALAAQVGG IGIAPGANIG DECALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSVILS AEMMLRHMGW TEAADLIVKG MEGAIAAKTV TYDFERLMEG
410
AKLLKCSEFG DAIIQHM
Length:417
Mass (Da):45,766
Last modified:December 15, 2003 - v1
Checksum:i0EFC80B0886E7DD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571868 Genomic DNA. Translation: CAE15175.1.
RefSeqiWP_011147021.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE15175; CAE15175; plu2801.
GeneIDi24170389.
KEGGiplu:plu2801.
PATRICi20509891. VBIPhoLum48522_3185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571868 Genomic DNA. Translation: CAE15175.1.
RefSeqiWP_011147021.1. NC_005126.1.

3D structure databases

ProteinModelPortaliQ7N3B7.
SMRiQ7N3B7. Positions 1-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu2801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE15175; CAE15175; plu2801.
GeneIDi24170389.
KEGGiplu:plu2801.
PATRICi20509891. VBIPhoLum48522_3185.

Organism-specific databases

GenoListiplu2801.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01Imported.

Entry informationi

Entry nameiQ7N3B7_PHOLL
AccessioniPrimary (citable) accession number: Q7N3B7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.