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Q7N2K3

- MEND_PHOLL

UniProt

Q7N2K3 - MEND_PHOLL

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:plu3073
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu3073.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5645642-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341796Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243265.plu3073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N2K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218360.
    KOiK02551.
    OMAiQKPWLLE.
    OrthoDBiEOG6NWBQW.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view]
    PfamiPF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7N2K3-1 [UniParc]FASTAAdd to Basket

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    MSNSAFNRRW AELLLEALTR HGLRHVCIAP GSRSTPLTIA AAANNKLICH    50
    THFDERGLGH LALGLSKASR EPVAVIVTSG TAVANLYPSL IEASLTGERM 100
    VFLTADRPPE LMDCGANQAI RQNGIFASHP CQTISLPRPT VDIPASWLAS 150
    VIDHSMANLQ HGAVHINCPF AEPLYGNEEP AYDEWQQQLG DWWKSKTPWL 200
    SQPVAKVVAE VPDWDCWQQK KGVVLAGRMS AEEGVNVAKW AKALSWPLIG 250
    NALSQTGQPL PCADLWLDNP HVQEILAQAQ LVVQFGSSLI GKCLLQWQAK 300
    CQPQEFWIID PIPGRLDPAN HRGKKLTCHI ADWLLAHPAQ PCIPWAQSCT 350
    LWAEELIVWS EKAVNCVRTE LAGKFGEATV AYRLRELLPE RGQLFVGNSL 400
    IIRLIDTLGQ LPAGYPVYSN RGASGIDGLI STAAGVQRAT AKPTLAVIGD 450
    LSALYDLNSL ALLRHPSAPM VLIVVNNNGG QIFSLLPTQE EARQRFYCMP 500
    QYVNFDHAAA MFGLKYASPQ NWMELQQSIK QAWQQNETTL IELKVPDREG 550
    AECLQQLLKQ VAML 564
    Length:564
    Mass (Da):62,123
    Last modified:December 15, 2003 - v1
    Checksum:i114D626C10D4EDAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571869 Genomic DNA. Translation: CAE15447.1.
    RefSeqiNP_930305.1. NC_005126.1.
    WP_011147290.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE15447; CAE15447; plu3073.
    GeneIDi2803084.
    KEGGiplu:plu3073.
    PATRICi20510496. VBIPhoLum48522_3487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571869 Genomic DNA. Translation: CAE15447.1 .
    RefSeqi NP_930305.1. NC_005126.1.
    WP_011147290.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N2K3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu3073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE15447 ; CAE15447 ; plu3073 .
    GeneIDi 2803084.
    KEGGi plu:plu3073.
    PATRICi 20510496. VBIPhoLum48522_3487.

    Organism-specific databases

    GenoListi plu3073.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218360.
    KOi K02551.
    OMAi QKPWLLE.
    OrthoDBi EOG6NWBQW.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view ]
    Pfami PF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiMEND_PHOLL
    AccessioniPrimary (citable) accession number: Q7N2K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3