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Q7N288

- FADJ_PHOLL

UniProt

Q7N288 - FADJ_PHOLL

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Protein

Fatty acid oxidation complex subunit alpha

Gene
fadJ, plu3200
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities By similarity.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei133 – 1331Important for catalytic activity By similarity
Sitei155 – 1551Important for catalytic activity By similarity

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-HAMAP
  2. 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB-HAMAP
  3. enoyl-CoA hydratase activity Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid degradation, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alpha
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC:4.2.1.17, EC:5.1.2.3)
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Gene namesi
Name:fadJ
Ordered Locus Names:plu3200
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu3200.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Fatty acid oxidation complex subunit alphaUniRule annotationPRO_0000109303Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI) By similarity.

Protein-protein interaction databases

STRINGi243265.plu3200.

Structurei

3D structure databases

ProteinModelPortaliQ7N288.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 205190Enoyl-CoA hydratase By similarityAdd
BLAST
Regioni321 – 7274073-hydroxyacyl-CoA dehydrogenase By similarityAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000261346.
KOiK01782.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01617. FadJ.
InterProiIPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR02440. FadJ. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N288-1 [UniParc]FASTAAdd to Basket

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MTQAQHDAAP ITTGTNQTAS VFSFDVRPDK IGIITINVPG EKVNTLKAEF    50
VDQFLNVFKQ AQQSSGLKGL ILISGKPDTF IAGADISMIA GCKTKEDARD 100
LAEKGQKLFS QIANYPLPVV AAIHGACLGG GLELALACHW RVCSQDDKTR 150
LGLPEVQLGL LPGSGGTQRL PRLIGVSSAL DIMLTGKQLR AKQALRLGLV 200
DDAVPLDILL DIAIEKVKKG IPVRKPLPWQ QRLLVGPVGR YFLFNIVRKK 250
TLAKTRGHYP APERIIEVVK EGLEKGMSQG LRAEAVAFGE LAMTRESAAL 300
RNLFFAATSL KNETGSSEKP AKIKHVGILG GGLMGGGIAN VTATRGKLPV 350
RIKDINEKGI SQVLKYTWDL LSKRVKQKRL RPAERAQQMM LISGTTDYRG 400
FAQTDIVVEA VFEDLSLKQK MVAEIETNAK PETIFASNTS SLPIHQIAEK 450
AQRPEQVIGL HYFSPVDKMP LVEVIPHQGT SEKTIATAVS LAKKQGKTAI 500
VVGDKAGFYV NRILVPYISE AAHCLVAGEP IDHIDGALVN FGFPVGPINL 550
LDEVGIDVGT KIMPVLVEQL GPRFAAPESL DAVLKDGRKG RKNGRGFYLY 600
APGPRKFWQF GKRDKKVDSS VYTLLNITPE SHMLSSEIAQ RCVMLMLNEA 650
VRCLDEGIIR SPRDGDIGAV FGIGFPPFFG GPFRYIDSLG CARVVEILRR 700
LESQYGDRFV PCECLVNMAE QNKSFYP 727
Length:727
Mass (Da):79,265
Last modified:December 6, 2005 - v2
Checksum:i5173D0EE51FB2930
GO

Sequence cautioni

The sequence CAE15574.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571869 Genomic DNA. Translation: CAE15574.1. Different initiation.
RefSeqiNP_930429.2. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE15574; CAE15574; plu3200.
GeneIDi2803211.
KEGGiplu:plu3200.
PATRICi20510816. VBIPhoLum48522_3649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571869 Genomic DNA. Translation: CAE15574.1 . Different initiation.
RefSeqi NP_930429.2. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu3200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE15574 ; CAE15574 ; plu3200 .
GeneIDi 2803211.
KEGGi plu:plu3200.
PATRICi 20510816. VBIPhoLum48522_3649.

Organism-specific databases

GenoListi plu3200.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000261346.
KOi K01782.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

UniPathwayi UPA00659 .

Family and domain databases

Gene3Di 1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPi MF_01617. FadJ.
InterProi IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR02440. FadJ. 1 hit.
PROSITEi PS00067. 3HCDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiFADJ_PHOLL
AccessioniPrimary (citable) accession number: Q7N288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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