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Q7N199

- GCSP_PHOLL

UniProt

Q7N199 - GCSP_PHOLL

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, plu3596
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:plu3596
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu3596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi243265.plu3596.

Structurei

3D structure databases

ProteinModelPortaliQ7N199.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N199-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEN QGEFIRRHIG SSAEQQKEML ATVGASSLND LTQKIVPRDI    50
ALPEPPDVGG GATEQQALAE LKAIASQNKR YQSYIGMGYA PAVLPPVILR 100
NLLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTIDLTGL DIASASLLDE 150
ATAAAEAMAM AKRISKLKNA DRFFVADDIH PQTLDVVRTR AETFGFDVIV 200
DKAEKVLELD GVFGVLLQQV GTTGEVHDYA DLIAQLKQRK IIVSVAADLM 250
ALLLLTAPGK QGADMVFGSA QRFGVPMGYG GPHAAFFASR DEFKRSMPGR 300
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTAQVL LANIAAMYAV 350
YHGSKGLKRI AGRIHRLTDI LAVGLQKAGF TLRYKTWFDT LTVEVADKAA 400
VLARAEKAEI NLRTDTYGAV GITLSEATRR DDVIKLFSVL TGTDDKLDVE 450
ALDKELMTES HSIPASMLRS DEILLHPNFN RYHSETDMMR YMHRLERRDL 500
ALNQAMIPLG SCTMKLNAAA EMLPISWPEF NELHPFCPPE QAQGYQQMIS 550
QLSHWLVQLT GYDVVCMQPN SGAQGEYAGL LAIRRYHESR GEGHRHICLI 600
PSSAHGTNPA SAHMAGMTVV VVSCDKEGNI DLVDLREKAE ESGNELSCIM 650
VTYPSTHGVY EETIRQVCEI IHQYGGQVYL DGANMNAQVG ITAPGFIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFLPGHSVV QMDGLTEQRA 750
VSAAPFGSAS ILPISWMYIR MMGSQGLKQA SQTAILNANY IAARLKNDYD 800
VLYTGHNGYV AHECILDIRP LKEEFGISEM DIAKRLIDYG FHAPTMSFPV 850
AGTLMVEPTE SESKVEIDRF VDAMLAIRAE IGKVAKGEWS LEDNPLVNAP 900
HVQAELVSDW SHSYSRETAV FPTLETKANK YWPAVKRLDD VYGDRNLHCS 950
CAPVSDYQ 958
Length:958
Mass (Da):105,143
Last modified:December 15, 2003 - v1
Checksum:i2379AB181E054E0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571871 Genomic DNA. Translation: CAE15969.1.
RefSeqiNP_930808.1. NC_005126.1.
WP_011147763.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE15969; CAE15969; plu3596.
GeneIDi2803608.
KEGGiplu:plu3596.
PATRICi20511688. VBIPhoLum48522_4085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571871 Genomic DNA. Translation: CAE15969.1 .
RefSeqi NP_930808.1. NC_005126.1.
WP_011147763.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu3596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE15969 ; CAE15969 ; plu3596 .
GeneIDi 2803608.
KEGGi plu:plu3596.
PATRICi 20511688. VBIPhoLum48522_4085.

Organism-specific databases

GenoListi plu3596.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiGCSP_PHOLL
AccessioniPrimary (citable) accession number: Q7N199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi