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Q7N199 (GCSP_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:plu3596
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166922

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N199 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 2379AB181E054E0B

FASTA958105,143
        10         20         30         40         50         60 
MTQTLSQLEN QGEFIRRHIG SSAEQQKEML ATVGASSLND LTQKIVPRDI ALPEPPDVGG 

        70         80         90        100        110        120 
GATEQQALAE LKAIASQNKR YQSYIGMGYA PAVLPPVILR NLLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLESLLNF QQVTIDLTGL DIASASLLDE ATAAAEAMAM AKRISKLKNA DRFFVADDIH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFDVIV DKAEKVLELD GVFGVLLQQV GTTGEVHDYA DLIAQLKQRK 

       250        260        270        280        290        300 
IIVSVAADLM ALLLLTAPGK QGADMVFGSA QRFGVPMGYG GPHAAFFASR DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTAQVL LANIAAMYAV YHGSKGLKRI 

       370        380        390        400        410        420 
AGRIHRLTDI LAVGLQKAGF TLRYKTWFDT LTVEVADKAA VLARAEKAEI NLRTDTYGAV 

       430        440        450        460        470        480 
GITLSEATRR DDVIKLFSVL TGTDDKLDVE ALDKELMTES HSIPASMLRS DEILLHPNFN 

       490        500        510        520        530        540 
RYHSETDMMR YMHRLERRDL ALNQAMIPLG SCTMKLNAAA EMLPISWPEF NELHPFCPPE 

       550        560        570        580        590        600 
QAQGYQQMIS QLSHWLVQLT GYDVVCMQPN SGAQGEYAGL LAIRRYHESR GEGHRHICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAHMAGMTVV VVSCDKEGNI DLVDLREKAE ESGNELSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIRQVCEI IHQYGGQVYL DGANMNAQVG ITAPGFIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFLPGHSVV QMDGLTEQRA VSAAPFGSAS ILPISWMYIR MMGSQGLKQA 

       790        800        810        820        830        840 
SQTAILNANY IAARLKNDYD VLYTGHNGYV AHECILDIRP LKEEFGISEM DIAKRLIDYG 

       850        860        870        880        890        900 
FHAPTMSFPV AGTLMVEPTE SESKVEIDRF VDAMLAIRAE IGKVAKGEWS LEDNPLVNAP 

       910        920        930        940        950 
HVQAELVSDW SHSYSRETAV FPTLETKANK YWPAVKRLDD VYGDRNLHCS CAPVSDYQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571871 Genomic DNA. Translation: CAE15969.1.
RefSeqNP_930808.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu3596.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE15969; CAE15969; plu3596.
GeneID2803608.
KEGGplu:plu3596.
PATRIC20511688. VBIPhoLum48522_4085.

Organism-specific databases

GenoListplu3596.
CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQPANEEQ.
OrthoDBEOG6HMXDX.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PHOLL
AccessionPrimary (citable) accession number: Q7N199
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families