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Q7N199

- GCSP_PHOLL

UniProt

Q7N199 - GCSP_PHOLL

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:plu3596
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu3596.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_0000166922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi243265.plu3596.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiQPANEEQ.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7N199-1 [UniParc]FASTAAdd to Basket

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    MTQTLSQLEN QGEFIRRHIG SSAEQQKEML ATVGASSLND LTQKIVPRDI    50
    ALPEPPDVGG GATEQQALAE LKAIASQNKR YQSYIGMGYA PAVLPPVILR 100
    NLLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTIDLTGL DIASASLLDE 150
    ATAAAEAMAM AKRISKLKNA DRFFVADDIH PQTLDVVRTR AETFGFDVIV 200
    DKAEKVLELD GVFGVLLQQV GTTGEVHDYA DLIAQLKQRK IIVSVAADLM 250
    ALLLLTAPGK QGADMVFGSA QRFGVPMGYG GPHAAFFASR DEFKRSMPGR 300
    IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTAQVL LANIAAMYAV 350
    YHGSKGLKRI AGRIHRLTDI LAVGLQKAGF TLRYKTWFDT LTVEVADKAA 400
    VLARAEKAEI NLRTDTYGAV GITLSEATRR DDVIKLFSVL TGTDDKLDVE 450
    ALDKELMTES HSIPASMLRS DEILLHPNFN RYHSETDMMR YMHRLERRDL 500
    ALNQAMIPLG SCTMKLNAAA EMLPISWPEF NELHPFCPPE QAQGYQQMIS 550
    QLSHWLVQLT GYDVVCMQPN SGAQGEYAGL LAIRRYHESR GEGHRHICLI 600
    PSSAHGTNPA SAHMAGMTVV VVSCDKEGNI DLVDLREKAE ESGNELSCIM 650
    VTYPSTHGVY EETIRQVCEI IHQYGGQVYL DGANMNAQVG ITAPGFIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFLPGHSVV QMDGLTEQRA 750
    VSAAPFGSAS ILPISWMYIR MMGSQGLKQA SQTAILNANY IAARLKNDYD 800
    VLYTGHNGYV AHECILDIRP LKEEFGISEM DIAKRLIDYG FHAPTMSFPV 850
    AGTLMVEPTE SESKVEIDRF VDAMLAIRAE IGKVAKGEWS LEDNPLVNAP 900
    HVQAELVSDW SHSYSRETAV FPTLETKANK YWPAVKRLDD VYGDRNLHCS 950
    CAPVSDYQ 958
    Length:958
    Mass (Da):105,143
    Last modified:December 15, 2003 - v1
    Checksum:i2379AB181E054E0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571871 Genomic DNA. Translation: CAE15969.1.
    RefSeqiNP_930808.1. NC_005126.1.
    WP_011147763.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE15969; CAE15969; plu3596.
    GeneIDi2803608.
    KEGGiplu:plu3596.
    PATRICi20511688. VBIPhoLum48522_4085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571871 Genomic DNA. Translation: CAE15969.1 .
    RefSeqi NP_930808.1. NC_005126.1.
    WP_011147763.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu3596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE15969 ; CAE15969 ; plu3596 .
    GeneIDi 2803608.
    KEGGi plu:plu3596.
    PATRICi 20511688. VBIPhoLum48522_4085.

    Organism-specific databases

    GenoListi plu3596.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi QPANEEQ.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiGCSP_PHOLL
    AccessioniPrimary (citable) accession number: Q7N199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3