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Q7N199

- GCSP_PHOLL

UniProt

Q7N199 - GCSP_PHOLL

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:plu3596
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu3596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_0000166922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu3596.

Structurei

3D structure databases

ProteinModelPortaliQ7N199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTLSQLEN QGEFIRRHIG SSAEQQKEML ATVGASSLND LTQKIVPRDI
60 70 80 90 100
ALPEPPDVGG GATEQQALAE LKAIASQNKR YQSYIGMGYA PAVLPPVILR
110 120 130 140 150
NLLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTIDLTGL DIASASLLDE
160 170 180 190 200
ATAAAEAMAM AKRISKLKNA DRFFVADDIH PQTLDVVRTR AETFGFDVIV
210 220 230 240 250
DKAEKVLELD GVFGVLLQQV GTTGEVHDYA DLIAQLKQRK IIVSVAADLM
260 270 280 290 300
ALLLLTAPGK QGADMVFGSA QRFGVPMGYG GPHAAFFASR DEFKRSMPGR
310 320 330 340 350
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTAQVL LANIAAMYAV
360 370 380 390 400
YHGSKGLKRI AGRIHRLTDI LAVGLQKAGF TLRYKTWFDT LTVEVADKAA
410 420 430 440 450
VLARAEKAEI NLRTDTYGAV GITLSEATRR DDVIKLFSVL TGTDDKLDVE
460 470 480 490 500
ALDKELMTES HSIPASMLRS DEILLHPNFN RYHSETDMMR YMHRLERRDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMLPISWPEF NELHPFCPPE QAQGYQQMIS
560 570 580 590 600
QLSHWLVQLT GYDVVCMQPN SGAQGEYAGL LAIRRYHESR GEGHRHICLI
610 620 630 640 650
PSSAHGTNPA SAHMAGMTVV VVSCDKEGNI DLVDLREKAE ESGNELSCIM
660 670 680 690 700
VTYPSTHGVY EETIRQVCEI IHQYGGQVYL DGANMNAQVG ITAPGFIGAD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFLPGHSVV QMDGLTEQRA
760 770 780 790 800
VSAAPFGSAS ILPISWMYIR MMGSQGLKQA SQTAILNANY IAARLKNDYD
810 820 830 840 850
VLYTGHNGYV AHECILDIRP LKEEFGISEM DIAKRLIDYG FHAPTMSFPV
860 870 880 890 900
AGTLMVEPTE SESKVEIDRF VDAMLAIRAE IGKVAKGEWS LEDNPLVNAP
910 920 930 940 950
HVQAELVSDW SHSYSRETAV FPTLETKANK YWPAVKRLDD VYGDRNLHCS

CAPVSDYQ
Length:958
Mass (Da):105,143
Last modified:December 15, 2003 - v1
Checksum:i2379AB181E054E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571871 Genomic DNA. Translation: CAE15969.1.
RefSeqiNP_930808.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE15969; CAE15969; plu3596.
GeneIDi2803608.
KEGGiplu:plu3596.
PATRICi20511688. VBIPhoLum48522_4085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571871 Genomic DNA. Translation: CAE15969.1 .
RefSeqi NP_930808.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu3596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE15969 ; CAE15969 ; plu3596 .
GeneIDi 2803608.
KEGGi plu:plu3596.
PATRICi 20511688. VBIPhoLum48522_4085.

Organism-specific databases

GenoListi plu3596.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiGCSP_PHOLL
AccessioniPrimary (citable) accession number: Q7N199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3