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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:plu3681
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514 Componenti: Chromosome

Organism-specific databases

GenoListiplu3681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Biosynthetic arginine decarboxylasePRO_0000149967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ7N121.

Interactioni

Protein-protein interaction databases

STRINGi243265.plu3681.

Structurei

3D structure databases

ProteinModelPortaliQ7N121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 29311Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDNIARKMQ QTYNIAYWGG SYYYVNDLGN VSVCPNPDLP GAKIDLAELV
60 70 80 90 100
KRVQQEQKHL RLPALFCFPQ ILQHRLRSIN AAFKRARESY GYKGDYFLVY
110 120 130 140 150
PIKVNQQRRV IESLASSGEP LGLEAGSKAE LMAVLAHAGM TRTVIVCNGY
160 170 180 190 200
KDREYIRLAL IGEKLGHKVY LVIEKMSEIA QVLEEAERLN VIPRLGVRAR
210 220 230 240 250
LASQGSGKWQ ASGGEKSKFG LAATQVLQLV ETLRAVDRLD SLQLLHFHLG
260 270 280 290 300
SQLANIRDIA TGVRESARFY VELHKLGVNI QCFDVGGGLG VDYEGTRSQS
310 320 330 340 350
DCSVNYGLNE YANNVIWGIG DACDEHGLPH PTVITESGRA LTAHHTVLVS
360 370 380 390 400
NVIGVERNEF TQTTPPAEDA SRPLTSLWET WQEMHSEGNR RSLRESLHDG
410 420 430 440 450
QLDLHDVHTQ YAHGMLDLTE RAWAEELYLN ICRRIQQDLD PSNRAHRPII
460 470 480 490 500
DELQERMADK FYVNFSLFQS LPDAWGIDQL FPVLPIEGLD KPLDRRAVLL
510 520 530 540 550
DITCDSDGIV DHYVDGDGVA ATMPMPAYDP DCPPMIGFFM VGAYQEILGN
560 570 580 590 600
MHNLFGDTAA IDVYVFDNGE VTYNQSEEGD SVADMLQYVK LDPNVLMARF
610 620 630
RDQVKGADLD TGLQEQFLLE FESGLYGYTY LEDE
Length:634
Mass (Da):71,155
Last modified:December 14, 2003 - v1
Checksum:iA3268D93070FDCB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571871 Genomic DNA. Translation: CAE16054.1.
RefSeqiNP_930889.1. NC_005126.1.
WP_011147844.1. NC_005126.1.

Genome annotation databases

KEGGiplu:plu3681.
PATRICi20511872. VBIPhoLum48522_4177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571871 Genomic DNA. Translation: CAE16054.1.
RefSeqiNP_930889.1. NC_005126.1.
WP_011147844.1. NC_005126.1.

3D structure databases

ProteinModelPortaliQ7N121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu3681.

Proteomic databases

PRIDEiQ7N121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiplu:plu3681.
PATRICi20511872. VBIPhoLum48522_4177.

Organism-specific databases

GenoListiplu3681.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiSPEA_PHOLL
AccessioniPrimary (citable) accession number: Q7N121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2004
Last sequence update: December 14, 2003
Last modified: March 31, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.