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Q7MZX2 (DSBD_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbD
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase
Short name=Disulfide reductase
Gene names
Name:dsbD
Ordered Locus Names:plu4139
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 575551Thiol:disulfide interchange protein DsbD HAMAP MF_00399
PRO_0000304391

Regions

Transmembrane180 – 20021Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane367 – 38721Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane425 – 44521Helical; Potential
Domain444 – 575132Thioredoxin

Amino acid modifications

Disulfide bond126 ↔ 132Redox-active By similarity
Disulfide bond192 ↔ 314Redox-active By similarity
Disulfide bond490 ↔ 493Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MZX2 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: CBEC7F62BF5E7852

FASTA57564,073
        10         20         30         40         50         60 
MIKRTLMLFL LLCSPLLTPA AANALFEQPG QNPYLPVDQA FMFDFQQKGD KLTLDWQIKP 

        70         80         90        100        110        120 
GYYLYHKQLH IEPQQATLGK ITLPQGTAHR DEFFGETEVY FQQLIVNVPV TKANNNSNIV 

       130        140        150        160        170        180 
VTYQGCAAAG YCYPPETRLV PLSAVIPSKT TDAISAEPVH KTPESASNDQ QHLPFSPLWA 

       190        200        210        220        230        240 
ILIGIGIAFT PCVLPMYPLI SSIILGSQRP KSLKQIFWLA LSYVQGMAVT YTLLGLIVAA 

       250        260        270        280        290        300 
AGLQFQAALQ HPYVLIGLSV LFILLALSMF GLYSLQLPSA VQTRLVNWSN QQKNGSLFGV 

       310        320        330        340        350        360 
FAMGALAGLI CSPCTTAPLS AILLYIAQSG NTVAGGLTLY LYALGMGLPL IAVTLFGHKL 

       370        380        390        400        410        420 
LPRSGPWMQY VKEAFGFIIL ALPVFLLERV IGDAWGIRLW SLLAVSFLGW GFVLTIRSQN 

       430        440        450        460        470        480 
GWVRVIQLIL LILMLIATRP LQDWFWGTTV TQQSQHSLNF RQINNWQELE QIMTQNSHKT 

       490        500        510        520        530        540 
VMLDFYADWC TACKEFEKYT FSDPQVQSQL GDTLLLQANV TNNSPQQKQL LEKLSVRGLP 

       550        560        570 
TILFFDSQGK EIPDSRVNGF MDATRFNEHL QHLPK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571872 Genomic DNA. Translation: CAE16511.1.
RefSeqNP_931329.1. NC_005126.1.

3D structure databases

HSSPHSSP built from PDB template 1VRS based on UniProtKB P36655.
ProteinModelPortalQ7MZX2.
SMRQ7MZX2. Positions 34-148, 453-571.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2804151.
GenomeReviewsGene locus plu4139 in contig BX470251_GR.
KEGGplu:plu4139.
NMPDRfig|243265.1.peg.3952.
PATRIC20512870. VBIPhoLum48522_4677.

Organism-specific databases

GenoListplu4139.
CMRSearch...

Phylogenomic databases

HOGENOMHBG640883.
OMATHILWAG.
PhylomeDBQ7MZX2.
ProtClustDBPRK00293.

Enzyme and pathway databases

BioCycPLUM243265:PLU4139-MONOMER.

Family and domain databases

HAMAPMF_00399. DbsD.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM_dom.
IPR022910. Thiol_diS_interchange_DbsD.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK04084.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBD_PHOLL
AccessionPrimary (citable) accession number: Q7MZX2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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