Thiol:disulfide interchange protein dsbD precursor - Photorhabdus luminescens subsp. laumondii

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Reviewed, UniProtKB/Swiss-Prot Q7MZX2 (DSBD_PHOLL)

Last modified June 16, 2009. Version 48. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase

Gene names

Name:	dsbD
Ordered Locus Names:	plu4139

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

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Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.
Catalytic activity	Protein dithiol + NAD(P)⁺ = protein disulfide + NAD(P)H. HAMAP MF_00399
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbD subfamily. Contains 1 thioredoxin domain.

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Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Electron transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Redox-active center Signal Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro cytochrome complex assembly Inferred from electronic annotation. Source: HAMAP electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: HAMAP protein-disulfide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 575

551

Thiol:disulfide interchange protein dsbD HAMAP MF_00399

PRO_0000304391

Regions

Transmembrane

180 – 200

Potential

Transmembrane

216 – 236

Potential

Transmembrane

253 – 273

Potential

Transmembrane

297 – 317

Potential

Transmembrane

336 – 356

Potential

Transmembrane

367 – 387

Potential

Transmembrane

394 – 414

Potential

Transmembrane

425 – 445

Potential

Domain

444 – 575

132

Thioredoxin

Amino acid modifications

Disulfide bond

126 ↔ 132

Redox-active By similarity

Disulfide bond

192 ↔ 314

Redox-active By similarity

Disulfide bond

490 ↔ 493

Redox-active By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q7MZX2-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: CBEC7F62BF5E7852
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FASTA

575

64,073

        10         20         30         40         50         60 
MIKRTLMLFL LLCSPLLTPA AANALFEQPG QNPYLPVDQA FMFDFQQKGD KLTLDWQIKP 

        70         80         90        100        110        120 
GYYLYHKQLH IEPQQATLGK ITLPQGTAHR DEFFGETEVY FQQLIVNVPV TKANNNSNIV 

       130        140        150        160        170        180 
VTYQGCAAAG YCYPPETRLV PLSAVIPSKT TDAISAEPVH KTPESASNDQ QHLPFSPLWA 

       190        200        210        220        230        240 
ILIGIGIAFT PCVLPMYPLI SSIILGSQRP KSLKQIFWLA LSYVQGMAVT YTLLGLIVAA 

       250        260        270        280        290        300 
AGLQFQAALQ HPYVLIGLSV LFILLALSMF GLYSLQLPSA VQTRLVNWSN QQKNGSLFGV 

       310        320        330        340        350        360 
FAMGALAGLI CSPCTTAPLS AILLYIAQSG NTVAGGLTLY LYALGMGLPL IAVTLFGHKL 

       370        380        390        400        410        420 
LPRSGPWMQY VKEAFGFIIL ALPVFLLERV IGDAWGIRLW SLLAVSFLGW GFVLTIRSQN 

       430        440        450        460        470        480 
GWVRVIQLIL LILMLIATRP LQDWFWGTTV TQQSQHSLNF RQINNWQELE QIMTQNSHKT 

       490        500        510        520        530        540 
VMLDFYADWC TACKEFEKYT FSDPQVQSQL GDTLLLQANV TNNSPQQKQL LEKLSVRGLP 

       550        560        570 
TILFFDSQGK EIPDSRVNGF MDATRFNEHL QHLPK

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References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens."
Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K.

Kunst F.
Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TT01.

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Cross-references

Sequence databases
	BX571872 Genomic DNA. Translation: CAE16511.1.
RefSeq	NP_931329.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPE based on UniProtKB P36655.
ModBase	Search...
Genome annotation databases
GeneID	2804151.
GenomeReviews	Gene locus plu4139 in contig BX470251_GR.
KEGG	plu:plu4139.
NMPDR	fig\|243265.1.peg.3952.
Organism-specific databases
PhotoList	plu4139.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MZX2.
OMA	Q7MZX2. TITHILW.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU4139-MON.
BRENDA	1.8.1.8. 308689.
Family and domain databases
HAMAP	MF_00399. [Tree]
InterPro	IPR003834. Cyt_c_assmbl_TM. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF02683. DsbD. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

DSBD_PHOLL

Accession

Primary (citable) accession number: Q7MZX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents