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Protein

Antitoxin HicB 2

Gene

hicB2

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin preventing effects of the HicA 2 toxin (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi96 – 113H-T-H motifBy similarityAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin HicB 2
Gene namesi
Name:hicB2
Ordered Locus Names:plu4354
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045211 – 139Antitoxin HicB 2Add BLAST139

Interactioni

Subunit structurei

Probably forms a complex with the probable mRNA interferase HicA2 (its cognate toxin); when complexed with HicA inhibits the toxin activity.By similarity

Protein-protein interaction databases

STRINGi243265.plu4354.

Structurei

3D structure databases

ProteinModelPortaliQ7MZD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 137HTH cro/C1-typeAdd BLAST51

Sequence similaritiesi

Belongs to the HicB antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105PF0. Bacteria.
COG1598. LUCA.
HOGENOMiHOG000219259.
KOiK18843.
OMAiCYKREDI.
OrthoDBiPOG091H0I4F.

Family and domain databases

InterProiIPR031807. HicB-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF15919. HicB_lk_antitox. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MZD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNMRYPVK FEHDETGWAV MFPDIPEALT GGDTREEALA MAQDALVTAF
60 70 80 90 100
DFYFEDRREI PTPSTKGEAF VEVPASIAAK VLLLNTMLQT RTSNAELARL
110 120 130
LGTRPQEIQR IVSLSHSTKI DTIANALNAL GKHLELVAI
Length:139
Mass (Da):15,387
Last modified:December 15, 2003 - v1
Checksum:i98DD626271593A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571873 Genomic DNA. Translation: CAE16726.1.

Genome annotation databases

EnsemblBacteriaiCAE16726; CAE16726; plu4354.
KEGGiplu:plu4354.
PATRICi20513378. VBIPhoLum48522_4930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571873 Genomic DNA. Translation: CAE16726.1.

3D structure databases

ProteinModelPortaliQ7MZD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu4354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE16726; CAE16726; plu4354.
KEGGiplu:plu4354.
PATRICi20513378. VBIPhoLum48522_4930.

Phylogenomic databases

eggNOGiENOG4105PF0. Bacteria.
COG1598. LUCA.
HOGENOMiHOG000219259.
KOiK18843.
OMAiCYKREDI.
OrthoDBiPOG091H0I4F.

Family and domain databases

InterProiIPR031807. HicB-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF15919. HicB_lk_antitox. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHICB2_PHOLL
AccessioniPrimary (citable) accession number: Q7MZD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.