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Q7MZ76

- PCP2_PHOLL

UniProt

Q7MZ76 - PCP2_PHOLL

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Protein

Pyrrolidone-carboxylate peptidase 2

Gene

pcp2

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831UniRule annotation
Active sitei146 – 1461UniRule annotation
Active sitei170 – 1701UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase 2UniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidase 2UniRule annotation
Pyroglutamyl-peptidase I 2UniRule annotation
Short name:
PGP-I 2UniRule annotation
Short name:
Pyrase 2UniRule annotation
Gene namesi
Name:pcp2UniRule annotation
Ordered Locus Names:plu4418
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu4418.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Pyrrolidone-carboxylate peptidase 2PRO_0000184727Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu4418.

Structurei

3D structure databases

ProteinModelPortaliQ7MZ76.
SMRiQ7MZ76. Positions 4-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiCYEMELE.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MZ76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTQKTVLIT GFEPFGKETI NPSWEAAKQL QGRELCGARV EARQLPCVFD
60 70 80 90 100
VSLACLYAAI DDVQPDLVIA VGQAGGRPNI TVERVAININ DASIPDNQGN
110 120 130 140 150
QPINTPIVAT GPAAYFATLP INAIVKGLRD AGVPASISQT AGTFVCNHVM
160 170 180 190 200
YGLLHHLACI YPEIRGGVLH IPYLPEQAAR YSGTPSMALE TVITALEIAI
210
DEALKNSEDI ANNGDTAH
Length:218
Mass (Da):23,158
Last modified:December 15, 2003 - v1
Checksum:i6519209111AB823C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571873 Genomic DNA. Translation: CAE16790.1.
RefSeqiNP_931591.1. NC_005126.1.
WP_011148508.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE16790; CAE16790; plu4418.
GeneIDi2804439.
KEGGiplu:plu4418.
PATRICi20513550. VBIPhoLum48522_5011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571873 Genomic DNA. Translation: CAE16790.1 .
RefSeqi NP_931591.1. NC_005126.1.
WP_011148508.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7MZ76.
SMRi Q7MZ76. Positions 4-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu4418.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE16790 ; CAE16790 ; plu4418 .
GeneIDi 2804439.
KEGGi plu:plu4418.
PATRICi 20513550. VBIPhoLum48522_5011.

Organism-specific databases

GenoListi plu4418.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi CYEMELE.
OrthoDBi EOG6X1124.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiPCP2_PHOLL
AccessioniPrimary (citable) accession number: Q7MZ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3