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Q7MZ76 (PCP2_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrrolidone-carboxylate peptidase 2

EC=3.4.19.3
Alternative name(s):
5-oxoprolyl-peptidase 2
Pyroglutamyl-peptidase I 2
Short name=PGP-I 2
Short name=Pyrase 2
Gene names
Name:pcp2
Ordered Locus Names:plu4418
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417

Catalytic activity

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00417.

Sequence similarities

Belongs to the peptidase C15 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

pyroglutamyl-peptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Pyrrolidone-carboxylate peptidase 2 HAMAP-Rule MF_00417
PRO_0000184727

Sites

Active site831 By similarity
Active site1461 By similarity
Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MZ76 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 6519209111AB823C

FASTA21823,158
        10         20         30         40         50         60 
MTTQKTVLIT GFEPFGKETI NPSWEAAKQL QGRELCGARV EARQLPCVFD VSLACLYAAI 

        70         80         90        100        110        120 
DDVQPDLVIA VGQAGGRPNI TVERVAININ DASIPDNQGN QPINTPIVAT GPAAYFATLP 

       130        140        150        160        170        180 
INAIVKGLRD AGVPASISQT AGTFVCNHVM YGLLHHLACI YPEIRGGVLH IPYLPEQAAR 

       190        200        210 
YSGTPSMALE TVITALEIAI DEALKNSEDI ANNGDTAH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571873 Genomic DNA. Translation: CAE16790.1.
RefSeqNP_931591.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7MZ76.
SMRQ7MZ76. Positions 4-212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu4418.

Protein family/group databases

MEROPSC15.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE16790; CAE16790; plu4418.
GeneID2804439.
KEGGplu:plu4418.
PATRIC20513550. VBIPhoLum48522_5011.

Organism-specific databases

GenoListplu4418.
CMRSearch...

Phylogenomic databases

eggNOGCOG2039.
HOGENOMHOG000242641.
KOK01304.
OMANCDDARI.
OrthoDBEOG6X1124.
ProtClustDBPRK13197.

Family and domain databases

Gene3D3.40.630.20. 1 hit.
HAMAPMF_00417. Pyrrolid_peptidase.
InterProIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERPTHR23402. PTHR23402. 1 hit.
PfamPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSPR00706. PYROGLUPTASE.
SUPFAMSSF53182. SSF53182. 1 hit.
TIGRFAMsTIGR00504. pyro_pdase. 1 hit.
PROSITEPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCP2_PHOLL
AccessionPrimary (citable) accession number: Q7MZ76
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries