ID   Q7MYN2_PHOLL            Unreviewed;       856 AA.
AC   Q7MYN2;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:CAE17015.1};
GN   OrderedLocusNames=plu4643 {ECO:0000313|EMBL:CAE17015.1};
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01) (Photorhabdus luminescens subsp. laumondii).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265 {ECO:0000313|EMBL:CAE17015.1, ECO:0000313|Proteomes:UP000002514};
RN   [1] {ECO:0000313|Proteomes:UP000002514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01
RC   {ECO:0000313|Proteomes:UP000002514};
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; BX571874; CAE17015.1; -; Genomic_DNA.
DR   RefSeq; WP_011148714.1; NC_005126.1.
DR   AlphaFoldDB; Q7MYN2; -.
DR   STRING; 243265.plu4643; -.
DR   GeneID; 24169095; -.
DR   KEGG; plu:plu4643; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002514}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   856 AA;  98638 MW;  501AE4B56EBC55B3 CRC64;
     MYLYIETLKQ RLDAINQLRL ERASTAMSAE FKQVYSLLPV LLHYHHSMMP GYINGNVPYG
     VCFFVHDEAQ KSYLNDLENK LDHFIEQPAN GELPITGIYS MGSTSSIGQS GCSDLDIWVC
     HQSWLDNDER LLLQRKCTLI EQWAAALGIE VNFFLIDENR FRHNASGSLG GEDCGSTQHI
     LLLDEFYRTA VRMAGKRLLW EMVPVEEERH YDEYVLSLYA QGVLTPNEWL DLGGLGELSA
     EEYFGASLWQ LYKSIDSPYK AVLKSLLLEA YSWEYPNGKL LAMEMKQRLH AGEIVSFGLD
     AYSMMLERVT RYLIEINDTT RLDLIRRCFY LKVCEKLSLN QDDKGCIGWR RQVLTQLIYE
     WKWDPERLKI LDNRNLWKIE QVRDAHNELL DTMMQSYRNL IRFARRNNLS VSASPQDIGV
     LTRKLYAAFE ALPGKVTLVN PQISPDLSEK NLTFIYVPQG RANRSGWYLY NQAPAIGSII
     GHQPLEYNRY LNKLVSWTYF NGLLTEKSCI HIHHGETQCD ELKLHELIND ISTHFPIRLP
     SPTPKALYSP CEIRHLAIIV NLEKDPTAEF SNQVVHFDFR KLDVFSFGES QQCLVESIDL
     LYRNSWNEVR TLHFSGGQSV LEALKTILGK MHQDAAPPAA VEVFCYSEHL RGLIRTRIQQ
     LVSECIELRL SSNRQDPGRF KALRIAGQTW GLFFERLNVS VQKLENAVEF YGAISNNKLH
     GLPVKINTKE THLPAVVDGF ASEGIIQFFF ENTQDNQSFN IYILDETNRV EIYSHCEGSK
     EELVRDVSRF YSSSHDRFTY GSSFINFNLP QFYQIVQMKG QIQVIPFSGS SFSHLCVAHD
     GENEEQPELY RSVSHY
//