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Q7MYL1

- GPPA_PHOLL

UniProt

Q7MYL1 - GPPA_PHOLL

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:plu4666
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu4666.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194284Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243265.plu4666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MYL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MYL1-1 [UniParc]FASTAAdd to Basket

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    MLSSSSLYAA IDLGSNSFHM LVVREVSGSM QILARIKRKV RLAAGLDKNN    50
    RLSQQAMERG WQCLRIFSER LQDIPPSQIR VVATATLRIA ENSDEFVGKA 100
    SEILDCPVKV ISGEDEARLI YQGVAHTTGG PEKRLVVDIG GASTELVTGN 150
    GAKASQLSSL SMGCVTWLEG YFNDRSLTEE NFARAEAAAH ETLKLIAPKL 200
    IEQGWQICVG ASGTVQALQE IMIAQGMDEL ITLPKLQELK HKAIECGKLE 250
    ELEIEGLTLE RALVFPSGLA ILIAIFQALN IESMILAGGA LREGLVYGML 300
    DLPIEPDIRT RTLRNIQRRF QLDVEQSQRV KQLAEHFLQQ VAKPWELDSR 350
    CHELLQSACL IHEIGLSIDF HQAPSHAAYL INYLALPGYT PAQKKLLATL 400
    LKNQSGPIDL FSFNQQNALP LIQAQRLCRL LRLAIIFANR RRNDTLPALR 450
    LKVSDEALTI TLPHGWLMQH PLRAESLQQE IQWQNHAQWS LVLGEQDAQT 500
    Length:500
    Mass (Da):55,603
    Last modified:December 15, 2003 - v1
    Checksum:i54F2DA33EEC8D8C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571874 Genomic DNA. Translation: CAE17038.1.
    RefSeqiNP_931828.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE17038; CAE17038; plu4666.
    GeneIDi2804697.
    KEGGiplu:plu4666.
    PATRICi20514110. VBIPhoLum48522_5283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571874 Genomic DNA. Translation: CAE17038.1 .
    RefSeqi NP_931828.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7MYL1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu4666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE17038 ; CAE17038 ; plu4666 .
    GeneIDi 2804697.
    KEGGi plu:plu4666.
    PATRICi 20514110. VBIPhoLum48522_5283.

    Organism-specific databases

    GenoListi plu4666.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiGPPA_PHOLL
    AccessioniPrimary (citable) accession number: Q7MYL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3