Reviewed, UniProtKB/Swiss-Prot Q7MYD5 (ARGE_PHOLL)

Names and origin

Protein names

Recommended name:
    Acetylornithine deacetylase
      Short name=Acetylornithinase
      Short name=AO
    EC=3.5.1.16
Alternative name(s):
    N-acetylornithinase
      Short name=NAO

Gene names

Name:	argE
Ordered Locus Names:	plu4745

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. Glutathione By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: HAMAP cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Acetylornithine deacetylase HAMAP MF_01108		PRO_0000185247
Sites
	Active site	82	1	By similarity
	Active site	144	1	Proton acceptor By similarity
	Metal binding	80	1	Cobalt or zinc 1 By similarity
	Metal binding	112	1	Cobalt or zinc 1 By similarity
	Metal binding	112	1	Cobalt or zinc 2 By similarity
	Metal binding	145	1	Cobalt or zinc 2 By similarity
	Metal binding	169	1	Cobalt or zinc 1 By similarity
	Metal binding	355	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MYD5-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 7386C4144745A023	FASTA	385	42,701
	10 20 30 40 50 60 MNIKLPPFIE LFRQLIATPS ISATDISIDQ SNESLINLLA SWLKEIGFEI EIQPVPETLG 70 80 90 100 110 120 KYNLLATLGR GPGGLLLCGH TDTVPFDEGL WTKDPFTLTE RDNKLYGLGT ADMKGFFAFI 130 140 150 160 170 180 IDALRDIDVS KITRPLYILA TADEETTMAG ARYFAASTTI RPDFAIIGEP TSLHPICAHK 190 200 210 220 230 240 GHLSNAIRIV GQSGHSSDPD RGINAIDLMH ESIGHLIELR NTLKEHYNNP AFTIPYPTMN 250 260 270 280 290 300 FGYIHGGDAV NRICAHCELH MDIRPLPGLT LQDLNGLLNE ALEPMKQRWP GRLTIDELHS 310 320 330 340 350 360 PIPGYECPTD HKMVDVIEKL LGRKAETVNY CTEAPFIQKV CPTLVLGPGS IEQAHQPDEF 370 380 IDMSFIGPTR KIISQLIDHF CLSNN

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571874 Genomic DNA. Translation: CAE17117.1.
RefSeq	NP_931907.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M20.974.
Genome annotation databases
GeneID	2804792.
GenomeReviews	Gene locus plu4745 in contig BX470251_GR.
KEGG	plu:plu4745.
NMPDR	fig|243265.1.peg.4530.
Organism-specific databases
PhotoList	plu4745.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MYD5.
OMA	LIIQVIH.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU4745-MON.
BRENDA	3.5.1.16. 308689.
Family and domain databases
HAMAP	MF_01108. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_PHOLL

Accession

Primary (citable) accession number: Q7MYD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 15, 2003
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)