Q7MXZ1 (DNAA_PORGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	PG_0001

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114231
Regions
	Nucleotide binding	178 – 185	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7MXZ1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: B3DF207837F3CCD9	FASTA	473	53,362
	10 20 30 40 50 60 MNYHSTNVNE IWDACLRILQ DIVDERAYRT WFLPIIPVSI EGDTLTLQVP SQFFCEFLEG 70 80 90 100 110 120 NFVEQLRTVL GRVIGPNASL QYNALVDNSS PKYPGTVTLA GCADGGQAAE QFDVNLLHRH 130 140 150 160 170 180 MPNAATHSEA QDFDTQLNSR LNFRNFYQSE CNYVARSVAE AIAASPGNTP MNPFFIYGAS 190 200 210 220 230 240 GVGKTHLCHA LGLRVREMHP RLKVLYVSSH LFEMQFTTAA RMGTINDFIA FYQQVDVLII 250 260 270 280 290 300 DDIQWLIGKK KTQLAFFQVF NHLYMLGKQI VLTSDKPPVD LNGMEERLVT RMAGATCVKI 310 320 330 340 350 360 ERPDLKLRRE ILQQRTLQSG VRLDESVLNF IAENVCDNVR ELEGTLVSLI TNSVVVGKEI 370 380 390 400 410 420 DLTFAKRIVR QAVRLEKKEV TIECIQQAVS RVFQVQIEQM KSKSRKQDIV QARQVVMFLS 430 440 450 460 470 KKHTAQSLSA IGELMGGRNH ATVLHGCRCV TNEMEMNASF RSSVERAEQL IAN

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ65259.1.
RefSeq	NP_904360.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MXZ1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2551501.
GenomeReviews	Gene locus PG_0001 in contig AE015924_GR.
KEGG	pgi:PG0001.
NMPDR	fig|242619.1.peg.1.
PATRIC	22977158. VBIPorGin134034_0001.
TIGR	PG_0001.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q7MXZ1.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_PORGI

Accession

Primary (citable) accession number: Q7MXZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program