Q7MXT7 (LPXD_PORGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	PG_0072

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000059689
Sites
	Active site	240	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MXT7 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 3F311B5C3BAF17F6	FASTA	349	37,403
	10 20 30 40 50 60 MEFTAQQIAD YLHGSVEGNP KVRLHDFAKI EEGRSGCLSF LANAKYEHYL YQTQSDAVLV 70 80 90 100 110 120 NQDFEPRESV KTTLIRVPNA YTALAQLMQL VDSMKPQRKG VDSTAFVHPS VILPDDCYVG 130 140 150 160 170 180 AFAYVSEGAS LGTGCSLYPH VYVGSGVSVG EGTILYPHVT VYDGCSIGSR CVIHSGAVIG 190 200 210 220 230 240 ADGFGFAPNA EGYSKIPQLG NVIIEDDVEI GANTCIDRAV MDSTIIHRGV KLDNLVQIAH 250 260 270 280 290 300 NCSVGSHTVF AAQVGMAGSS HVGEWCQFGG QVGLSGHIKV GDRVSLGGQT GLLSNVKSGS 310 320 330 340 TLLGSPGMPL RDMLRASVIF PKLPDMSLRI EQLEKEISEL KEICKNNKH

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ65321.1.
RefSeq	NP_904422.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MXT7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2552395.
GenomeReviews	Gene locus PG_0072 in contig AE015924_GR.
KEGG	pgi:PG0072.
NMPDR	fig|242619.1.peg.63.
PATRIC	22977292. VBIPorGin134034_0065.
TIGR	PG_0072.
Phylogenomic databases
HOGENOM	HBG469615.
OMA	DSTIIHR.
PhylomeDB	Q7MXT7.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_0072-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 3 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_PORGI

Accession

Primary (citable) accession number: Q7MXT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program