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Q7MXP4 (HEMH_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:PG_0127
OrganismPorphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]
Taxonomic identifier242619 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ferrochelatase HAMAP MF_00323
PRO_0000175178

Sites

Metal binding1991Iron By similarity
Metal binding3021Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MXP4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 1A4D7EFBB870012F

FASTA34539,561
        10         20         30         40         50         60 
MADRRRTDDN KGAREVVLLL NIGSPDSPEE KDVARYLNSF LTDRRIITLP FLLRQLLVRG 

        70         80         90        100        110        120 
IITPFRKKSS AQKYRTVWDE STRSFPLISH TKAIARALAH TGREVHVAMR YGKPAVADVL 

       130        140        150        160        170        180 
KELPHGRSLV VLPLFPHYAM SSYETAVEHC KAEIRRLCPN LSFRVVQPFY AHEAYIRVLA 

       190        200        210        220        230        240 
DNIRPYLTKP FDKLILSYHG IPRDHLDKTT RQALNLRHPE GCCTEEDPTA NVCYRYQTYR 

       250        260        270        280        290        300 
TTALIREALG LAEEQVEQVF QSRVGHTEWL RPYLIERLSA WPQEETKRIL IACPSFVCDC 

       310        320        330        340 
LESLEEVADH GQSIFKKAGG ADFTYIPCLN SGANWIDALR NILEE

« Hide

References

[1]"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. expand/collapse author list , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.
J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015924 Genomic DNA. Translation: AAQ65369.1.
RefSeqNP_904470.1. NC_002950.2.

3D structure databases

ProteinModelPortalQ7MXP4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2552580.
GenomeReviewsGene locus PG_0127 in contig AE015924_GR.
KEGGpgi:PG0127.
NMPDRfig|242619.1.peg.111.
PATRIC22977402. VBIPorGin134034_0115.
TIGRPG_0127.

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBQ7MXP4.
ProtClustDBCLSK2305817.

Enzyme and pathway databases

BioCycPGIN242619:PG_0127-MONOMER.
BRENDA4.99.1.1. 4997.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_PORGI
AccessionPrimary (citable) accession number: Q7MXP4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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