SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7MWT9

- LUXS_PORGI

UniProt

Q7MWT9 - LUXS_PORGI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

S-ribosylhomocysteine lyase

Gene
luxS, PG_0498
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron By similarity
Metal bindingi57 – 571Iron By similarity
Metal bindingi124 – 1241Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14563.
PGIN242619:GHX8-450-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:PG_0498
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159S-ribosylhomocysteine lyaseUniRule annotationPRO_0000298019Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi242619.PG0498.

Structurei

3D structure databases

ProteinModelPortaliQ7MWT9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
KOiK07173.
OMAiDLISWLF.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MWT9-1 [UniParc]FASTAAdd to Basket

« Hide

MEKIPSFQLD HIRLKRGIYV SRKDYIGGEV VTTFDIRMKE PNREPVLGAP    50
ELHTIEHLAA TYLRNHPLYK DRIVFWGPMG CLTGNYFLMR GDYVSKDILP 100
LMQETFRFIR DFEGEVPGTE PRDCGNCLLH NLPMAKYEAE KYLREVLDVA 150
TEENLNYPD 159
Length:159
Mass (Da):18,554
Last modified:December 15, 2003 - v1
Checksum:iA56C9F19EF27E37B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65692.1.
RefSeqiNP_904793.1. NC_002950.2.
WP_010956044.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65692; AAQ65692; PG_0498.
GeneIDi2552279.
KEGGipgi:PG0498.
PATRICi22978092. VBIPorGin134034_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65692.1 .
RefSeqi NP_904793.1. NC_002950.2.
WP_010956044.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MWT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0498.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65692 ; AAQ65692 ; PG_0498 .
GeneIDi 2552279.
KEGGi pgi:PG0498.
PATRICi 22978092. VBIPorGin134034_0457.

Phylogenomic databases

eggNOGi COG1854.
KOi K07173.
OMAi DLISWLF.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14563.
PGIN242619:GHX8-450-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiLUXS_PORGI
AccessioniPrimary (citable) accession number: Q7MWT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3