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Protein

Guanylate kinase

Gene

gmk

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:PG_0512
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705821 – 188Guanylate kinaseAdd BLAST188

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0512.

Structurei

3D structure databases

ProteinModelPortaliQ7MWS7.
SMRiQ7MWS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 183Guanylate kinase-likeUniRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAFIEHAQ.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MWS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLIIISAP SGTGKSTVIE RLLTDRELNL HFSISATSRA PRGEEQNGRE
60 70 80 90 100
YYFLSPEEFR RRIEANEFVE YEEVYRDKYY GTLKSEVERI LKEEKNVIFD
110 120 130 140 150
VDVVGAQSIK KYYGDRALAI FILPPSIEEL RSRLQKRGTD SMETIKQRVD
160 170 180
KAEKEIGYAH LFDLRFVNDD LVTCVEQIRK AIAQFIAK
Length:188
Mass (Da):21,849
Last modified:December 15, 2003 - v1
Checksum:iB98B008F4ADCF66D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ65706.1.
RefSeqiWP_004585052.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65706; AAQ65706; PG_0512.
GeneIDi2552249.
KEGGipgi:PG_0512.
PATRICi22978116. VBIPorGin134034_0469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ65706.1.
RefSeqiWP_004585052.1. NC_002950.2.

3D structure databases

ProteinModelPortaliQ7MWS7.
SMRiQ7MWS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi242619.PG0512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ65706; AAQ65706; PG_0512.
GeneIDi2552249.
KEGGipgi:PG_0512.
PATRICi22978116. VBIPorGin134034_0469.

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAFIEHAQ.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKGUA_PORGI
AccessioniPrimary (citable) accession number: Q7MWS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 15, 2003
Last modified: April 12, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.