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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:PG_0577
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei99 – 119HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21
Transmembranei328 – 348HelicalUniRule annotationAdd BLAST21
Transmembranei396 – 416HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088661 – 419Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST419

Proteomic databases

PRIDEiQ7MWM6

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0577

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
KOiK01000
OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MWM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLFDYLE KLQLPGARLF HYVSFRSAVA IVLALLLATV IGNRIIERLR
60 70 80 90 100
KAQIGETIRD LGLEGQLSKK GTPTMGGLII IISILIPTLL LARLDNVYIL
110 120 130 140 150
LMIVTTVLLG SLGFLDDYIK VFRKKKEGLH GRYKIIGQVG LGFIIGIVLY
160 170 180 190 200
MNPAVVIKEN SEVLRDGQVE RVHFNKQEVK STKTTIPFVK NNNFDYADIL
210 220 230 240 250
PLEGKTKVLF GWILFVCVAV VVVTFISNCA NLTDGLDGLA TGSSAIIGVV
260 270 280 290 300
LAIFAYVSSH IEMASYLNIM FIPGAEELTI FAFAFVGATI GFLWYNAYPA
310 320 330 340 350
QVFMGDTGSL TLGGIIAVFA LIIRKEMLLP ILCFVFIIEG LSVMIQVFYF
360 370 380 390 400
KLTKRRTGEG RRIFKMTPLH HHFQKPGNAG IDAWLQKPMQ AIPESKITVR
410
FWLVGIIMAA ITIATLKMR
Length:419
Mass (Da):46,633
Last modified:December 15, 2003 - v1
Checksum:i2E7AEDAF4B3C36DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ65764.1
RefSeqiWP_004585117.1, NC_002950.2

Genome annotation databases

EnsemblBacteriaiAAQ65764; AAQ65764; PG_0577
KEGGipgi:PG_0577

Similar proteinsi

Entry informationi

Entry nameiMRAY_PORGI
AccessioniPrimary (citable) accession number: Q7MWM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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