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Q7MW79

- PNP_PORGI

UniProt

Q7MW79 - PNP_PORGI

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, PG_0766
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891Magnesium By similarity
Metal bindingi495 – 4951Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-696-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:PG_0766
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0766.

Structurei

3D structure databases

ProteinModelPortaliQ7MW79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61863KH
Add
BLAST
Domaini628 – 69871S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MW79-1 [UniParc]FASTAAdd to Basket

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MLNVVSKTID LGDGRSIKIE TGKLAKQADG AVTVTMGNTV LLATVCAAKD    50
ANPGCDFMPL QVEYKEKYSA IGRFPGGFTR REGKASDYEI LTCRLVDRAL 100
RPLFPDNYHA EVFVNVILFS ADGEDMPDAL AGLAASAALA VSDIPFNGPI 150
SEVRVARVDG RYIVNPTFEQ LERADIDLMV GATMDNIMMV EGEMDEVQES 200
EMLEGIRVAH EAIKVQCKAQ LELSEAVGKL QKREYSHEVN DEDLRKKVHD 250
ECYARAYEVA TSGTGKHERG EAFEKIVEEF KAQYTEEELA EKAEMIARYY 300
HDVEKEAMRR AILDEGKRLD GRKTTEIRPI WIETDCLPGP HGSAIFTRGE 350
TQSLTTVTLG TKSDEKLVDD VLNYTKERFL LHYNFPPFST GEARPQRGVG 400
RREIGHGNLA HRALKRMIPT DYPYVVRVIS DILESNGSSS MATVCAGTLA 450
LRDAGVQIRK PVSGIAMGLI SENQGKNYAI LSDILGDEDH LGDMDFKVTG 500
TKDGITATQM DIKVDGLSYE ILENALEQAK QGRLHILGKI MEAQPETRDD 550
LKPHAPRIEK MHIGKEFIGA VIGPGGKIIQ GIQEKSGATV NIEEVDGMGV 600
IEISGTNKPC IDAAIGMIKG IVAMPEVGET YPGKITSVMP YGCFVEFLPG 650
KEGLLHISEV DWKRFETIED TNLKEGESIN VKLLDIDPKT GKFKLSRKVL 700
LEKPEGYVEP QPRERRERRE GGREGGRNFE RRGGDRDHRE PRG 743
Length:743
Mass (Da):82,258
Last modified:December 15, 2003 - v1
Checksum:iA7E47E1F8FDEB855
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65927.1.
RefSeqiNP_905028.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65927; AAQ65927; PG_0766.
GeneIDi2552025.
KEGGipgi:PG0766.
PATRICi22978598. VBIPorGin134034_0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65927.1 .
RefSeqi NP_905028.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MW79.
ModBasei Search...

Protein-protein interaction databases

STRINGi 242619.PG0766.

Protocols and materials databases

DNASUi 2552025.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65927 ; AAQ65927 ; PG_0766 .
GeneIDi 2552025.
KEGGi pgi:PG0766.
PATRICi 22978598. VBIPorGin134034_0703.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-696-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiPNP_PORGI
AccessioniPrimary (citable) accession number: Q7MW79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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