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Q7MW79

- PNP_PORGI

UniProt

Q7MW79 - PNP_PORGI

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891MagnesiumUniRule annotation
Metal bindingi495 – 4951MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-696-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:PG_0766
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Polyribonucleotide nucleotidyltransferasePRO_0000329762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0766.

Structurei

3D structure databases

ProteinModelPortaliQ7MW79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61863KHUniRule annotationAdd
BLAST
Domaini628 – 69871S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MW79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNVVSKTID LGDGRSIKIE TGKLAKQADG AVTVTMGNTV LLATVCAAKD
60 70 80 90 100
ANPGCDFMPL QVEYKEKYSA IGRFPGGFTR REGKASDYEI LTCRLVDRAL
110 120 130 140 150
RPLFPDNYHA EVFVNVILFS ADGEDMPDAL AGLAASAALA VSDIPFNGPI
160 170 180 190 200
SEVRVARVDG RYIVNPTFEQ LERADIDLMV GATMDNIMMV EGEMDEVQES
210 220 230 240 250
EMLEGIRVAH EAIKVQCKAQ LELSEAVGKL QKREYSHEVN DEDLRKKVHD
260 270 280 290 300
ECYARAYEVA TSGTGKHERG EAFEKIVEEF KAQYTEEELA EKAEMIARYY
310 320 330 340 350
HDVEKEAMRR AILDEGKRLD GRKTTEIRPI WIETDCLPGP HGSAIFTRGE
360 370 380 390 400
TQSLTTVTLG TKSDEKLVDD VLNYTKERFL LHYNFPPFST GEARPQRGVG
410 420 430 440 450
RREIGHGNLA HRALKRMIPT DYPYVVRVIS DILESNGSSS MATVCAGTLA
460 470 480 490 500
LRDAGVQIRK PVSGIAMGLI SENQGKNYAI LSDILGDEDH LGDMDFKVTG
510 520 530 540 550
TKDGITATQM DIKVDGLSYE ILENALEQAK QGRLHILGKI MEAQPETRDD
560 570 580 590 600
LKPHAPRIEK MHIGKEFIGA VIGPGGKIIQ GIQEKSGATV NIEEVDGMGV
610 620 630 640 650
IEISGTNKPC IDAAIGMIKG IVAMPEVGET YPGKITSVMP YGCFVEFLPG
660 670 680 690 700
KEGLLHISEV DWKRFETIED TNLKEGESIN VKLLDIDPKT GKFKLSRKVL
710 720 730 740
LEKPEGYVEP QPRERRERRE GGREGGRNFE RRGGDRDHRE PRG
Length:743
Mass (Da):82,258
Last modified:December 15, 2003 - v1
Checksum:iA7E47E1F8FDEB855
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65927.1.
RefSeqiNP_905028.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65927; AAQ65927; PG_0766.
GeneIDi2552025.
KEGGipgi:PG0766.
PATRICi22978598. VBIPorGin134034_0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65927.1 .
RefSeqi NP_905028.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MW79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0766.

Protocols and materials databases

DNASUi 2552025.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65927 ; AAQ65927 ; PG_0766 .
GeneIDi 2552025.
KEGGi pgi:PG0766.
PATRICi 22978598. VBIPorGin134034_0703.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-696-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiPNP_PORGI
AccessioniPrimary (citable) accession number: Q7MW79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3