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Q7MW49

- SYL_PORGI

UniProt

Q7MW49 - SYL_PORGI

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Protein

Leucine--tRNA ligase

Gene
leuS, PG_0796
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei703 – 7031ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PG_0796
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Leucine--tRNA ligaseUniRule annotationPRO_0000152062Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0796.

Structurei

3D structure databases

ProteinModelPortaliQ7MW49.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi700 – 7045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MW49-1 [UniParc]FASTAAdd to Basket

« Hide

MEYNFQEIEK RVQGQWRKDK VYRVAEDTSK KPFYVLDMFP YPSGAGLHVG    50
HPLGYIASDI FSRYKRLRGF NVLHPMGYDA FGLPAEQYAI QTGQHPEKTT 100
EENTARYREQ LDKIGFSYDW EREIRTCDPN YYKWTQWAFL KMFDSYYCNQ 150
AQQARPISEL IEVFARQGND GLNVACGEGV RFTAEEWTAM SEKEQQEILM 200
NYRLAYLGDT MVNWCPALGT VLANDEVKDG VSERGGHPVE QKKMRQWCLR 250
VSAYAERLLH DLETLDWTES LKETQRNWIG RSEGAEMEFR LAGKDCTFTI 300
FTTRADTIFG VTFMVLAPES ELVEEVTTEE QRAAVETYLT ETKRRTERER 350
ISDKRVSGVF SGSYAINPLT GKEIPIWISD YVLAGYGTGA IMAVPAHDTR 400
DFAFARHFDL PIVQVVVPEG EPATDPATWE DAKDSKSGIM VNSDFLNGLS 450
VEDAIAQTKE YIREKHLGCV KVNYRLRDAI FSRQRYWGEP FPIYYKEGMP 500
HALDEDRLPL RLPEVDKFLP TESGEPPLGR ATGWHTAEGY PYELSTMPGF 550
AGSSAYYLRY MDPQNDTALV SRSANEYWRH VDLYIGGTEH ATGHLIYSRF 600
WNKFLFDLGI VCEAEPFRKL VNQGMIQGRS NFVYRIKNTN TFVSYGLREQ 650
YEVTPLHVDV NIVSNDQLDI DRFRAWRPEY TSAEFILEDG KYICGWAIEK 700
MSKSMFNVVN PDDIIARYGA DTLRLYEMFL GPLEQSKPWD TNGIDGVHRF 750
LKKFWALYYN TDGIRVTDTA PTKEELKSLH KLIKKVGQDI ESFSFNTSIP 800
AFMICVNELT AAKTTSRAIL CPLLTVLSPF APHITEWLWQ ELGVEGSIVT 850
ATWPEYNEEY LVESCVRYPV SFNGKVRFNI ELPADMSKED VEQAALIAPE 900
AARWLEGKSP KKVIVVPGRI VNVVV 925
Length:925
Mass (Da):106,106
Last modified:December 15, 2003 - v1
Checksum:iE068D5CE1CC249A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65957.1.
RefSeqiNP_905058.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65957; AAQ65957; PG_0796.
GeneIDi2552799.
KEGGipgi:PG0796.
PATRICi22978658. VBIPorGin134034_0731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ65957.1 .
RefSeqi NP_905058.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MW49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65957 ; AAQ65957 ; PG_0796 .
GeneIDi 2552799.
KEGGi pgi:PG0796.
PATRICi 22978658. VBIPorGin134034_0731.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-728-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiSYL_PORGI
AccessioniPrimary (citable) accession number: Q7MW49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi