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Q7MW49

- SYL_PORGI

UniProt

Q7MW49 - SYL_PORGI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei703 – 7031ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPGIN242619:GHX8-728-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PG_0796
    OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
    Taxonomic identifieri242619 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
    ProteomesiUP000000588: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 925925Leucine--tRNA ligasePRO_0000152062Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242619.PG0796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MW49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi700 – 7045"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MW49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFQEIEK RVQGQWRKDK VYRVAEDTSK KPFYVLDMFP YPSGAGLHVG    50
    HPLGYIASDI FSRYKRLRGF NVLHPMGYDA FGLPAEQYAI QTGQHPEKTT 100
    EENTARYREQ LDKIGFSYDW EREIRTCDPN YYKWTQWAFL KMFDSYYCNQ 150
    AQQARPISEL IEVFARQGND GLNVACGEGV RFTAEEWTAM SEKEQQEILM 200
    NYRLAYLGDT MVNWCPALGT VLANDEVKDG VSERGGHPVE QKKMRQWCLR 250
    VSAYAERLLH DLETLDWTES LKETQRNWIG RSEGAEMEFR LAGKDCTFTI 300
    FTTRADTIFG VTFMVLAPES ELVEEVTTEE QRAAVETYLT ETKRRTERER 350
    ISDKRVSGVF SGSYAINPLT GKEIPIWISD YVLAGYGTGA IMAVPAHDTR 400
    DFAFARHFDL PIVQVVVPEG EPATDPATWE DAKDSKSGIM VNSDFLNGLS 450
    VEDAIAQTKE YIREKHLGCV KVNYRLRDAI FSRQRYWGEP FPIYYKEGMP 500
    HALDEDRLPL RLPEVDKFLP TESGEPPLGR ATGWHTAEGY PYELSTMPGF 550
    AGSSAYYLRY MDPQNDTALV SRSANEYWRH VDLYIGGTEH ATGHLIYSRF 600
    WNKFLFDLGI VCEAEPFRKL VNQGMIQGRS NFVYRIKNTN TFVSYGLREQ 650
    YEVTPLHVDV NIVSNDQLDI DRFRAWRPEY TSAEFILEDG KYICGWAIEK 700
    MSKSMFNVVN PDDIIARYGA DTLRLYEMFL GPLEQSKPWD TNGIDGVHRF 750
    LKKFWALYYN TDGIRVTDTA PTKEELKSLH KLIKKVGQDI ESFSFNTSIP 800
    AFMICVNELT AAKTTSRAIL CPLLTVLSPF APHITEWLWQ ELGVEGSIVT 850
    ATWPEYNEEY LVESCVRYPV SFNGKVRFNI ELPADMSKED VEQAALIAPE 900
    AARWLEGKSP KKVIVVPGRI VNVVV 925
    Length:925
    Mass (Da):106,106
    Last modified:December 15, 2003 - v1
    Checksum:iE068D5CE1CC249A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ65957.1.
    RefSeqiNP_905058.1. NC_002950.2.

    Genome annotation databases

    EnsemblBacteriaiAAQ65957; AAQ65957; PG_0796.
    GeneIDi2552799.
    KEGGipgi:PG0796.
    PATRICi22978658. VBIPorGin134034_0731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ65957.1 .
    RefSeqi NP_905058.1. NC_002950.2.

    3D structure databases

    ProteinModelPortali Q7MW49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242619.PG0796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ65957 ; AAQ65957 ; PG_0796 .
    GeneIDi 2552799.
    KEGGi pgi:PG0796.
    PATRICi 22978658. VBIPorGin134034_0731.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PGIN242619:GHX8-728-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.

    Entry informationi

    Entry nameiSYL_PORGI
    AccessioniPrimary (citable) accession number: Q7MW49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3