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Q7MVV7

- KITH_PORGI

UniProt

Q7MVV7 - KITH_PORGI

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Protein
Thymidine kinase
Gene
tdk, PG_0925
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton acceptor Reviewed prediction
Metal bindingi152 – 1521Zinc By similarity
Metal bindingi155 – 1551Zinc By similarity
Metal bindingi184 – 1841Zinc By similarity
Metal bindingi187 – 1871Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATP By similarity
Nucleotide bindingi95 – 984ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:PG_0925
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Thymidine kinaseUniRule annotation
PRO_0000175005Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi242619.PG0925.

Structurei

3D structure databases

ProteinModelPortaliQ7MVV7.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MVV7-1 [UniParc]FASTAAdd to Basket

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MDYEIENNHA DSIRRGSIEV ICGSMFSGKT EELLRRLRRA KIARQTVEIF    50
KPTIDIRYDE TDVVSHDKNA IASTPVDNSA NILLLSSQVD VVGIDEAQFF 100
DEGLVEVAQQ LADQGVRVVI AGLDMDFRRQ PFGPMPGLCA IADSVTKVHA 150
VCVECGRLAS YSFRRVQGDQ QVMLGELNEY SPLCRTCYRK CSSPPQTEEI 200
HSTI 204
Length:204
Mass (Da):22,741
Last modified:December 15, 2003 - v1
Checksum:i256F6C6396963C43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66060.1.
RefSeqiNP_905161.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66060; AAQ66060; PG_0925.
GeneIDi2552938.
KEGGipgi:PG0925.
PATRICi22978910. VBIPorGin134034_0853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66060.1 .
RefSeqi NP_905161.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MVV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66060 ; AAQ66060 ; PG_0925 .
GeneIDi 2552938.
KEGGi pgi:PG0925.
PATRICi 22978910. VBIPorGin134034_0853.

Phylogenomic databases

eggNOGi COG1435.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-839-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiKITH_PORGI
AccessioniPrimary (citable) accession number: Q7MVV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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