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Q7MVV7 (KITH_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:PG_0925
OrganismPorphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]
Taxonomic identifier242619 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175005

Regions

Nucleotide binding23 – 308ATP By similarity
Nucleotide binding95 – 984ATP By similarity

Sites

Active site961Proton acceptor Potential
Metal binding1521Zinc By similarity
Metal binding1551Zinc By similarity
Metal binding1841Zinc By similarity
Metal binding1871Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MVV7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 256F6C6396963C43

FASTA20422,741
        10         20         30         40         50         60 
MDYEIENNHA DSIRRGSIEV ICGSMFSGKT EELLRRLRRA KIARQTVEIF KPTIDIRYDE 

        70         80         90        100        110        120 
TDVVSHDKNA IASTPVDNSA NILLLSSQVD VVGIDEAQFF DEGLVEVAQQ LADQGVRVVI 

       130        140        150        160        170        180 
AGLDMDFRRQ PFGPMPGLCA IADSVTKVHA VCVECGRLAS YSFRRVQGDQ QVMLGELNEY 

       190        200 
SPLCRTCYRK CSSPPQTEEI HSTI 

« Hide

References

[1]"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. expand/collapse author list , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.
J. Bacteriol. 185:5591-5601(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015924 Genomic DNA. Translation: AAQ66060.1.
RefSeqNP_905161.1. NC_002950.2.

3D structure databases

ProteinModelPortalQ7MVV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242619.PG0925.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ66060; AAQ66060; PG_0925.
GeneID2552938.
KEGGpgi:PG0925.
PATRIC22978910. VBIPorGin134034_0853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
KOK00857.
OMAKVHAICV.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycPGIN242619:GHX8-839-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_PORGI
AccessionPrimary (citable) accession number: Q7MVV7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families