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Q7MVS9

- TRMB_PORGI

UniProt

Q7MVS9 - TRMB_PORGI

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, PG_0960
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421S-adenosyl-L-methionine By similarity
Binding sitei67 – 671S-adenosyl-L-methionine By similarity
Binding sitei94 – 941S-adenosyl-L-methionine By similarity
Active sitei116 – 1161 By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei150 – 1501Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPGIN242619:GHX8-871-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:PG_0960
    OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
    Taxonomic identifieri242619 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
    ProteomesiUP000000588: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171371Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242619.PG0960.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MVS9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 1944Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiGCGKGEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MVS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    METFPHVFQY PFAVLQQQES GFPLRGRWHT DFFHNDHPIV LELGCGRGEY    50
    TVGLGKRFPE KNFIGIDIKG ARMWAGAKES LQEGMSNVAF LRTDIELLDR 100
    FFAEGEVAEI WITFPDPQMK KVGKRLTGTR FLSLYDKVLE RGGRIHLKTD 150
    SPFLYTYTKA LVELNGLPVH EITDDLYGKG CVENEILGIR TYYEQQWLER 200
    GLTIKYISFG LGEPDCEYRE PDIEIEPDSY RSYNRSRRSQ AVPS 244
    Length:244
    Mass (Da):28,215
    Last modified:December 15, 2003 - v1
    Checksum:i3F1216F3B456D4A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66090.1.
    RefSeqiNP_905191.1. NC_002950.2.

    Genome annotation databases

    EnsemblBacteriaiAAQ66090; AAQ66090; PG_0960.
    GeneIDi2552988.
    KEGGipgi:PG0960.
    PATRICi22978980. VBIPorGin134034_0888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66090.1 .
    RefSeqi NP_905191.1. NC_002950.2.

    3D structure databases

    ProteinModelPortali Q7MVS9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 242619.PG0960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ66090 ; AAQ66090 ; PG_0960 .
    GeneIDi 2552988.
    KEGGi pgi:PG0960.
    PATRICi 22978980. VBIPorGin134034_0888.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi GCGKGEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci PGIN242619:GHX8-871-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.

    Entry informationi

    Entry nameiTRMB_PORGI
    AccessioniPrimary (citable) accession number: Q7MVS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 15, 2003
    Last modified: June 11, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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