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Q7MVS9

- TRMB_PORGI

UniProt

Q7MVS9 - TRMB_PORGI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421S-adenosyl-L-methionineUniRule annotation
Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
Binding sitei94 – 941S-adenosyl-L-methionineUniRule annotation
Active sitei116 – 1161By similarity
Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-871-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:PG_0960
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244tRNA (guanine-N(7)-)-methyltransferasePRO_0000171371Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0960.

Structurei

3D structure databases

ProteinModelPortaliQ7MVS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1944Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MVS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METFPHVFQY PFAVLQQQES GFPLRGRWHT DFFHNDHPIV LELGCGRGEY
60 70 80 90 100
TVGLGKRFPE KNFIGIDIKG ARMWAGAKES LQEGMSNVAF LRTDIELLDR
110 120 130 140 150
FFAEGEVAEI WITFPDPQMK KVGKRLTGTR FLSLYDKVLE RGGRIHLKTD
160 170 180 190 200
SPFLYTYTKA LVELNGLPVH EITDDLYGKG CVENEILGIR TYYEQQWLER
210 220 230 240
GLTIKYISFG LGEPDCEYRE PDIEIEPDSY RSYNRSRRSQ AVPS
Length:244
Mass (Da):28,215
Last modified:December 15, 2003 - v1
Checksum:i3F1216F3B456D4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ66090.1.
RefSeqiNP_905191.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66090; AAQ66090; PG_0960.
GeneIDi2552988.
KEGGipgi:PG0960.
PATRICi22978980. VBIPorGin134034_0888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA. Translation: AAQ66090.1 .
RefSeqi NP_905191.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MVS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66090 ; AAQ66090 ; PG_0960 .
GeneIDi 2552988.
KEGGi pgi:PG0960.
PATRICi 22978980. VBIPorGin134034_0888.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PGIN242619:GHX8-871-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiTRMB_PORGI
AccessioniPrimary (citable) accession number: Q7MVS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3