Q7MVE5 (SYN_PORGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Asparagine--tRNA ligase
EC=6.1.1.22

Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	PG_1121

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Asparagine--tRNA ligase HAMAP MF_00534		PRO_0000176441

Sequences

	Sequence		Length	Mass (Da)
	Q7MVE5 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: B6DA3CC719A4E175	FASTA	469	53,073
	10 20 30 40 50 60 MDKKMKRTRI ADALHGGLVG QEINIKGWVR TKRGNKAVNF IALNDGSTIH NMQIVADLAS 70 80 90 100 110 120 FDAAQMSQIT TGACIGVIGT LVESQGAGQS VEVQASAIEI YGTADPATYP LQKKGHTLEF 130 140 150 160 170 180 LREIAHLRPR TNTFGAIYRI RHHMAIAIHT FFHNKGYYYF HAPLITASDC EGAGQMFQVT 190 200 210 220 230 240 TLNPDSLPRT EEGQVDYRKD FFGRHTSLTV SGQLEGEMAA MALGGIYTFG PTFRAENSNT 250 260 270 280 290 300 PRHLAEFWMI EPEVAFLEIE DNMDLAEEFI KYCVQWALDN CMDDISFLSE HFDKELIDRL 310 320 330 340 350 360 KFVLEKPFVR LAYTEGIRIL EEAVKNGVKF EFPIYWGADL ASEHERYLVE VHFKTPVIMT 370 380 390 400 410 420 DYPKEIKSFY MKLNDDGKTV RGMDVLFPKI GEIIGGSERE ADYDKLVARA NEMGVPEKDI 430 440 450 460 WWYLDSRRYG TAPHSGFGLG FERLLLFVTG MSNIRDVIPF PRTPNNAEF

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ66230.1.
RefSeq	NP_905331.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MVE5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2553310.
GenomeReviews	Gene locus PG_1121 in contig AE015924_GR.
KEGG	pgi:PG1121.
NMPDR	fig|242619.1.peg.972.
PATRIC	22979292. VBIPorGin134034_1039.
TIGR	PG_1121.
Phylogenomic databases
HOGENOM	HBG745843.
OMA	AIHRFFH.
PhylomeDB	Q7MVE5.
ProtClustDB	PRK03932.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_1121-MONOMER.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01893.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00457. AsnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_PORGI

Accession

Primary (citable) accession number: Q7MVE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program