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Q7MUZ8

- FTHS_PORGI

UniProt

Q7MUZ8 - FTHS_PORGI

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-1196-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PG_1321
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1321.

Structurei

3D structure databases

ProteinModelPortaliQ7MUZ8.
SMRiQ7MUZ8. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MUZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIQIARD IELQRIEQIA ESIDLPVEQL EPYGRYTAKV PLSCIDEEKV
60 70 80 90 100
KKGNLILVTA ITPNKAGVGK TTVSIGLALG LNHIGKKAIV ALREPSLGPC
110 120 130 140 150
FGMKGGAAGG GYAQVLPMEN INLHFTGDFH AVTSAHNMIT ALLENYIYQN
160 170 180 190 200
RNTCDGLSEI LWKRVLDVND RSLRNAVTGL GTISDGIPRQ TGFDITPASE
210 220 230 240 250
IMAILCLAKD FEDLRSRLEN ILLGYTKEGA PFTVKDLGIA GSIAVLLKDA
260 270 280 290 300
IKPNLVQTTE HTPAFVHGGP FANIAHGCNS ILATKMALSF GEYAVTEAGF
310 320 330 340 350
GADLGAEKFL DIKCREMGVA PKLTVLVATL RALKLHGGVA ETEIKAPNAE
360 370 380 390 400
ALRRGLSNLD RHIYNLKKFG QQVIVAFNRF DTDEEEEISI VREHCIGQNV
410 420 430 440 450
GFAVNNAFAE GGKGAEELAK LVVEMVENKP SQPLKYAYEP ENPVKMKIEK
460 470 480 490 500
IAKEIYSAGS VVYSSKADGK LKKIAMQSLD HLPVCIAKTQ YSFSSDPKAK
510 520 530 540 550
GDVRGFELKV SDIIINRGAG MLVVIIGEIM RMPGLPKEPQ AVHIDIVDGF

IEGLS
Length:555
Mass (Da):60,075
Last modified:December 15, 2003 - v1
Checksum:i900DD71B42D28A9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66392.1.
RefSeqiNP_905493.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66392; AAQ66392; PG_1321.
GeneIDi2551977.
KEGGipgi:PG1321.
PATRICi22979674. VBIPorGin134034_1221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66392.1 .
RefSeqi NP_905493.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q7MUZ8.
SMRi Q7MUZ8. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG1321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66392 ; AAQ66392 ; PG_1321 .
GeneIDi 2551977.
KEGGi pgi:PG1321.
PATRICi 22979674. VBIPorGin134034_1221.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PGIN242619:GHX8-1196-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiFTHS_PORGI
AccessioniPrimary (citable) accession number: Q7MUZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 15, 2003
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3