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Q7MUZ8 (FTHS_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PG_1321
OrganismPorphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]
Taxonomic identifier242619 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199368

Sequences

Sequence LengthMass (Da)Tools
Q7MUZ8 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 900DD71B42D28A9F

FASTA55560,075
        10         20         30         40         50         60 
MKSDIQIARD IELQRIEQIA ESIDLPVEQL EPYGRYTAKV PLSCIDEEKV KKGNLILVTA 

        70         80         90        100        110        120 
ITPNKAGVGK TTVSIGLALG LNHIGKKAIV ALREPSLGPC FGMKGGAAGG GYAQVLPMEN 

       130        140        150        160        170        180 
INLHFTGDFH AVTSAHNMIT ALLENYIYQN RNTCDGLSEI LWKRVLDVND RSLRNAVTGL 

       190        200        210        220        230        240 
GTISDGIPRQ TGFDITPASE IMAILCLAKD FEDLRSRLEN ILLGYTKEGA PFTVKDLGIA 

       250        260        270        280        290        300 
GSIAVLLKDA IKPNLVQTTE HTPAFVHGGP FANIAHGCNS ILATKMALSF GEYAVTEAGF 

       310        320        330        340        350        360 
GADLGAEKFL DIKCREMGVA PKLTVLVATL RALKLHGGVA ETEIKAPNAE ALRRGLSNLD 

       370        380        390        400        410        420 
RHIYNLKKFG QQVIVAFNRF DTDEEEEISI VREHCIGQNV GFAVNNAFAE GGKGAEELAK 

       430        440        450        460        470        480 
LVVEMVENKP SQPLKYAYEP ENPVKMKIEK IAKEIYSAGS VVYSSKADGK LKKIAMQSLD 

       490        500        510        520        530        540 
HLPVCIAKTQ YSFSSDPKAK GDVRGFELKV SDIIINRGAG MLVVIIGEIM RMPGLPKEPQ 

       550 
AVHIDIVDGF IEGLS 

« Hide

References

[1]"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. expand/collapse author list , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.
J. Bacteriol. 185:5591-5601(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015924 Genomic DNA. Translation: AAQ66392.1.
RefSeqNP_905493.1. NC_002950.2.

3D structure databases

ProteinModelPortalQ7MUZ8.
SMRQ7MUZ8. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242619.PG1321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ66392; AAQ66392; PG_1321.
GeneID2551977.
KEGGpgi:PG1321.
PATRIC22979674. VBIPorGin134034_1221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycPGIN242619:GHX8-1196-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PORGI
AccessionPrimary (citable) accession number: Q7MUZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways