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Q7MUZ8

- FTHS_PORGI

UniProt

Q7MUZ8 - FTHS_PORGI

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPGIN242619:GHX8-1196-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:PG_1321
    OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
    Taxonomic identifieri242619 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
    ProteomesiUP000000588: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199368Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242619.PG1321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MUZ8.
    SMRiQ7MUZ8. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7MUZ8-1 [UniParc]FASTAAdd to Basket

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    MKSDIQIARD IELQRIEQIA ESIDLPVEQL EPYGRYTAKV PLSCIDEEKV    50
    KKGNLILVTA ITPNKAGVGK TTVSIGLALG LNHIGKKAIV ALREPSLGPC 100
    FGMKGGAAGG GYAQVLPMEN INLHFTGDFH AVTSAHNMIT ALLENYIYQN 150
    RNTCDGLSEI LWKRVLDVND RSLRNAVTGL GTISDGIPRQ TGFDITPASE 200
    IMAILCLAKD FEDLRSRLEN ILLGYTKEGA PFTVKDLGIA GSIAVLLKDA 250
    IKPNLVQTTE HTPAFVHGGP FANIAHGCNS ILATKMALSF GEYAVTEAGF 300
    GADLGAEKFL DIKCREMGVA PKLTVLVATL RALKLHGGVA ETEIKAPNAE 350
    ALRRGLSNLD RHIYNLKKFG QQVIVAFNRF DTDEEEEISI VREHCIGQNV 400
    GFAVNNAFAE GGKGAEELAK LVVEMVENKP SQPLKYAYEP ENPVKMKIEK 450
    IAKEIYSAGS VVYSSKADGK LKKIAMQSLD HLPVCIAKTQ YSFSSDPKAK 500
    GDVRGFELKV SDIIINRGAG MLVVIIGEIM RMPGLPKEPQ AVHIDIVDGF 550
    IEGLS 555
    Length:555
    Mass (Da):60,075
    Last modified:December 15, 2003 - v1
    Checksum:i900DD71B42D28A9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66392.1.
    RefSeqiNP_905493.1. NC_002950.2.

    Genome annotation databases

    EnsemblBacteriaiAAQ66392; AAQ66392; PG_1321.
    GeneIDi2551977.
    KEGGipgi:PG1321.
    PATRICi22979674. VBIPorGin134034_1221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66392.1 .
    RefSeqi NP_905493.1. NC_002950.2.

    3D structure databases

    ProteinModelPortali Q7MUZ8.
    SMRi Q7MUZ8. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242619.PG1321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ66392 ; AAQ66392 ; PG_1321 .
    GeneIDi 2551977.
    KEGGi pgi:PG1321.
    PATRICi 22979674. VBIPorGin134034_1221.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PGIN242619:GHX8-1196-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.

    Entry informationi

    Entry nameiFTHS_PORGI
    AccessioniPrimary (citable) accession number: Q7MUZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3