Q7MUX4 (PYRE_PORGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10

Gene names

Name:	pyrE
Ordered Locus Names:	PG_1353

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity. HAMAP MF_01208
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity. HAMAP MF_01208
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Orotate phosphoribosyltransferase HAMAP MF_01208		PRO_0000110721
Regions
	Region	123 – 131	9	5-phosphoribose 1-diphosphate binding By similarity
Sites
	Binding site	97	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	101	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	103	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	127	1	Orotate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MUX4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 86E75BC055A68215	FASTA	210	23,021
	10 20 30 40 50 60 MKTLGKLIAS KLIEVKAIKL QPNNPFTWAS GWKAPIYCDN RKTLSYPQIR SLIKLELARV 70 80 90 100 110 120 ISETFGDVEA IAGVATGAIA QGALVADLLG LPFVYVRSSP KDHGLENLVE GELKPNSKVV 130 140 150 160 170 180 VIEDLISTGG SSLKAAEAIR NFGCEVLGMV AVYTHGFPMA EQNFEKAEVK LVTLTDYDQV 190 200 210 IEEALRTGYI SAENVELLRE WRKSPETWGI

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ66417.1.
RefSeq	NP_905518.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MUX4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2551538.
GenomeReviews	Gene locus PG_1353 in contig AE015924_GR.
KEGG	pgi:PG1353.
NMPDR	fig|242619.1.peg.1159.
PATRIC	22979744. VBIPorGin134034_1256.
TIGR	PG_1353.
Phylogenomic databases
HOGENOM	HBG404341.
OMA	LPMTYVR.
PhylomeDB	Q7MUX4.
ProtClustDB	PRK00455.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_1353-MONOMER.
Family and domain databases
HAMAP	MF_01208. PyrE. [Tree]
InterPro	IPR004467. Or_phspho_trans_clade-1. IPR023031. Orotate_PribosylTferase. IPR000836. PRibTrfase. [Graphical view]
KO	K00762.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR00336. PyrE. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRE_PORGI

Accession

Primary (citable) accession number: Q7MUX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program