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Q7MUH6 (UPPP_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:PG_1538
OrganismPorphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]
Taxonomic identifier242619 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151176

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane260 – 28021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7MUH6 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 67B7B90A099534F2

FASTA28030,851
        10         20         30         40         50         60 
MTILQAIVLA IVEGLTEFLP VSSTGHMIIA EGIMGVESTS FVRAFTVMIQ FGAILSVLVL 

        70         80         90        100        110        120 
YRKRFFCFPV APRALGQGKG KEFMSRFDLY WKLLIALVPA VILGFLFEDW VDRMLGSVWV 

       130        140        150        160        170        180 
VAVVLFLGGI FMLFVDKLFA SSDRGEITYP KAFVIGLFQC LAIFLPGLSR SMATIVGGQQ 

       190        200        210        220        230        240 
QKLSRKAAAE FSFFLAVPTM LGATLLKAYK LYKEGGIEIF REHMTVLLVG NIVAFIVALA 

       250        260        270        280 
AIKFFIGFLT RYGFKAFGYY RILVGGLLIV LMLSGVSLAV 

« Hide

References

[1]"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. expand/collapse author list , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.
J. Bacteriol. 185:5591-5601(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015924 Genomic DNA. Translation: AAQ66577.1.
RefSeqNP_905678.1. NC_002950.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242619.PG1538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ66577; AAQ66577; PG_1538.
GeneID2553042.
KEGGpgi:PG1538.
PATRIC22980090. VBIPorGin134034_1428.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK826861.

Enzyme and pathway databases

BioCycPGIN242619:GHX8-1387-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PORGI
AccessionPrimary (citable) accession number: Q7MUH6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families