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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133L-tryptophanUniRule annotation1
Binding sitei186ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi145 – 147ATPUniRule annotation3
Nucleotide bindingi194 – 198ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:PG_2085
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366581 – 327Tryptophan--tRNA ligaseAdd BLAST327

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi242619.PG2085

Structurei

3D structure databases

ProteinModelPortaliQ7MT94
SMRiQ7MT94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi194 – 198"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MT94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVVSGIRP TGNLHLGNYF GAIRSFLDMQ HRYNCFFFIA DWHSLTTHPH
60 70 80 90 100
PDNIVRNVRT ILAEYLACGI DPEKATIYVQ SDVREVLELY LYLNMNAYLG
110 120 130 140 150
ELERTTSFKE KARKQPNNVN AGLLTYPTLM AADILIHRAV KVPVGKDQEQ
160 170 180 190 200
NMEMARKFAR RFNTIYEVDF FPEPESFSPG ATALKVPGLD GSGKMGKSEG
210 220 230 240 250
NAIYLADDAK TISKKVMKAV TDAGPEVPNS VKPEPVENLF SMLRIVSSDE
260 270 280 290 300
VYRHFDDLYN NCSIRYGDLK KQLAADIVAF TTPIRERILE IQADEAFLDR
310 320
VVREGAERAR ESAARTLAEV RHIIGFR
Length:327
Mass (Da):36,969
Last modified:December 15, 2003 - v1
Checksum:iC3B8A8983DC34FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ67045.1
RefSeqiWP_004584702.1, NC_002950.2

Genome annotation databases

EnsemblBacteriaiAAQ67045; AAQ67045; PG_2085
GeneIDi29255389
KEGGipgi:PG_2085

Similar proteinsi

Entry informationi

Entry nameiSYW_PORGI
AccessioniPrimary (citable) accession number: Q7MT94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health