Q7MT33 (Q7MT33_PORGI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid A disaccharide synthase EMBL AAQ67112.1

Gene names

Name:	lpxB EMBL AAQ67112.1
Ordered Locus Names:	PG_2162

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7MT33 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: C0B77F91BDFAD9D1	FASTA	383	42,970
	10 20 30 40 50 60 MRYFIVAGEA SGDLHASNLV RALKEHDPEA VFAFMGGDFL SEATGERPIF HYREVAFMGF 70 80 90 100 110 120 IPVLTHLGVI RRAGEHVQEQ MRAFNPDVVI AVDYPGFNMR YVLPFVREEL GKPIVYYISP 130 140 150 160 170 180 KVWAWKSWRI KTLKKYVDLM LCILPFEKDF FAGHDFPVIY VGNPCYDAVK QHMRPTIEEQ 190 200 210 220 230 240 ERSAKDSRQV ALLCGSRLLE VKENLPVMLR VMKQFPDYRP VIAGAPGLTI QDYTPFLPDD 250 260 270 280 290 300 SIPVVFGRTY EILRESKAAL VTSGTATLET ALIGTPQVVC YYIRGGRLTN LIFKYCFGTP 310 320 330 340 350 360 FISLTNLIAG RAVVPELFGA LFTEKRLAAS LSPLLDASSA ERQAQLSGYD SIRKSIGTDN 370 380 TSDKAARHII ARFAKDNARP SSL

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ67112.1.
RefSeq	NP_906213.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MT33.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2551474.
GenomeReviews	Gene locus PG_2162 in contig AE015924_GR.
KEGG	pgi:PG2162.
NMPDR	fig|242619.1.peg.1854.
PATRIC	22981302. VBIPorGin134034_2013.
TIGR	PG_2162.
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	Q7MT33.
ProtClustDB	CLSK2306189.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_2162-MONOMER.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7MT33_PORGI

Accession

Primary (citable) accession number: Q7MT33

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)