Q7MSZ3 (DXS_PORGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	PG_2217

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	634 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 634	634	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189138

Sequences

	Sequence		Length	Mass (Da)
	Q7MSZ3 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: F35F5F3E6E69E258	FASTA	634	70,289
	10 20 30 40 50 60 MMEVRPTTLI DHINSPADLR ALKPEQLPQV CRELRRYILE VLSVTPGHLG SSLGAVDFTV 70 80 90 100 110 120 ALHYVFDTPY DRIVWDVGHQ AYSHKILTGR REDFRHLRQW GGISGFPSPK ESEYDTFPAG 130 140 150 160 170 180 HASNSISAAL GMAVASAAKD EKRKVIAVIG DGSMTGGMAF EGLNNASSFP NNLLIILNDN 190 200 210 220 230 240 NMSIDRNVGG LNRYMVDILT SKTYNTIRYD LYKGLRKINL ISETNRKNLL RFNNSFKALL 250 260 270 280 290 300 ARESNLFEGF SIRYFGPVDG NNVLRLVEVL NQIKDMAGPK ILHLRTIKGK GYSPAEKQAT 310 320 330 340 350 360 IWHAPGEFDI KSGERKKGEN KPEPPKFQDV FGHTLVELAD RDERVVGVTP AMPTGCSMTF 370 380 390 400 410 420 LMKKYPNRAY DVGIAEGHAV TFSAGLAKEG LIPFCNIYSS FIQRGYDQVI HDVALSGSHV 430 440 450 460 470 480 VICLDRAGLV GEDGATHHGV FDMAFLRCVP DIVVASPLNE HELRNLMLTA YKGYDGPMVI 490 500 510 520 530 540 RYPRGKGVLT DWRNTPRLVE IARGRCLTEG EAIAFLSIGP IGNMVQKVVE RLAEKGVSAA 550 560 570 580 590 600 HYDMVFLKPL DEEMLHGIAK KFDTIISVED GCIQGGFGSA VMEFMADHDY HPRIRRVGVP 610 620 630 DRFIGQGSVP EQYADCGMDA DSLLHLTEEL LLHP

References

[1]

"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015924 Genomic DNA. Translation: AAQ67157.1.
RefSeq	NP_906258.1. NC_002950.2.
3D structure databases
ProteinModelPortal	Q7MSZ3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2551684.
GenomeReviews	Gene locus PG_2217 in contig AE015924_GR.
KEGG	pgi:PG2217.
NMPDR	fig|242619.1.peg.1899.
PATRIC	22981420. VBIPorGin134034_2068.
TIGR	PG_2217.
Phylogenomic databases
HOGENOM	HBG571647.
OMA	EAMNAHA.
PhylomeDB	Q7MSZ3.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	PGIN242619:PG_2217-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR011766. TPP_enzyme-bd_C. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_PORGI

Accession

Primary (citable) accession number: Q7MSZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program