Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7MR67 (NADK_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:WS1623
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290NAD kinase HAMAP-Rule MF_00361
PRO_0000229711

Regions

Nucleotide binding75 – 762NAD By similarity
Nucleotide binding148 – 1492NAD By similarity
Nucleotide binding189 – 1946NAD By similarity

Sites

Active site751Proton acceptor By similarity
Binding site1781NAD By similarity
Binding site2471NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MR67 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 4B8B821617DF4ABF

FASTA29032,262
        10         20         30         40         50         60 
MILMQPLSSL SKVGVILRPS SPSLKEFFLQ VRSLFEREGI EVMLDSISGG MIGIYGCDFQ 

        70         80         90        100        110        120 
RLCSESDMLV SIGGDGTLIS VVRRSYPYGK PILGINMGRL GFLTDVRQDE VEAFVQKLKA 

       130        140        150        160        170        180 
GEYRIDSRLM LEGELSSPKG TQRFFAFNEA IVTRRPISGM IHVKASIGEE PFNTYFGDGL 

       190        200        210        220        230        240 
IVATPTGSTA YNISAGGPVV YPYSKNMILT PICAHSLTQR PLVLPSEFEV ELEMLEGEFA 

       250        260        270        280        290 
NIVVDGQEIM DFGYGDRLRL KVAERPALLV HKKEHNYFQV LREKFSWGDA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571661 Genomic DNA. Translation: CAE10655.1.
RefSeqNP_907755.1. NC_005090.1.

3D structure databases

ProteinModelPortalQ7MR67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS1623.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE10655; CAE10655; WS1623.
GeneID2555415.
KEGGwsu:WS1623.
PATRIC24040212. VBIWolSuc63014_1518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAGPILHES.
OrthoDBEOG6PZXDR.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_WOLSU
AccessionPrimary (citable) accession number: Q7MR67
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families