Q7MNZ4 (UPPP_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	VV0570

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio vulnificus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151238
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7MNZ4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 027113DC9E8355DB	FASTA	267	29,156
	10 20 30 40 50 60 MSYFEAFVLA LIQGLTEFLP ISSSAHLILP SAILGWEDQG LAFDVAVHVG TLAAVVIYFR 70 80 90 100 110 120 KEVITLFAAL FASIFKGERS KEAKLAWMIV IATIPACIFG LVMKDVIEVY LRSAYVIATT 130 140 150 160 170 180 TIIFGLLLWW VDKNASLLDD EYQAGWKKAL FIGIAQALAM IPGTSRSGAT ITAALYLGFT 190 200 210 220 230 240 REAAARFSFL MSIPIITLAG SYLGLKLVTS GEPVHVGFLL TGIVTSFISA YLCIHLFLKM 250 260 ISRMGMTPFV IYRLILGVGL FAYLLMA

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YJ016.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC93334.1.
RefSeq	NP_933363.1. NC_005139.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	196600.VV0570.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC93334; BAC93334; BAC93334.
GeneID	2623338.
KEGG	vvy:VV0570.
PATRIC	20167938. VBIVibVul40472_0589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	WFIIVAT.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_VIBVY

Accession

Primary (citable) accession number: Q7MNZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program