Reviewed, UniProtKB/Swiss-Prot Q7MNY4 (GLNE_VIBVY)

Names and origin

Protein names

Recommended name:
    Glutamate-ammonia-ligase adenylyltransferase
    EC=2.7.7.42
Alternative name(s):
    [Glutamate--ammonia-ligase] adenylyltransferase
    Glutamine-synthetase adenylyltransferase
      Short name=ATase

Gene names

Name:	glnE
Ordered Locus Names:	VV0581

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	950 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Adenylation and deadenylation of glutamine synthetase By similarity.
Catalytic activity	ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP MF_00802
Sequence similarities	Belongs to the glnE family.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW [glutamate-ammonia-ligase] adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 950	950	Glutamate-ammonia-ligase adenylyltransferase HAMAP MF_00802		PRO_0000209284
Regions
	Region	94 – 305	212	GlnE 1 HAMAP MF_00802
	Region	611 – 832	222	GlnE 2 HAMAP MF_00802

Sequences

	Sequence		Length	Mass (Da)
	Q7MNY4-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 4E2E3D363CBF6C0C	FASTA	950	108,919
	10 20 30 40 50 60 MSLPSPLLPV AELAMQNAQQ SGYLEHWPQA LITQFQFISG LSKFVVETVQ RDAQLAEGLP 70 80 90 100 110 120 EMLAQESRQE AYRTRLAEQL QACHDEVAGH RVLRQFRNRE MVYIAWKDFT QAWSLEASLS 130 140 150 160 170 180 HLSELAEAMI FETYQWQYQL CCQEWGTPTN AQGEAQPMLI IGMGKLGGGE LNFSSDIDLI 190 200 210 220 230 240 FTYPENGETQ GARRSIANAQ FFTRLGQRLI KALDQQTFDG FCYRVDMRLR PFGESGPLVM 250 260 270 280 290 300 SYAALEDYYQ EQGRDWERYA MIKARVMGRE MYPEYQELRQ MLRPFVFRRY IDFSAIQSLR 310 320 330 340 350 360 RMKSMISSEV RRRGLSNNIK LGAGGIREIE FIAQVFQLIR GGREPALRQR GLLVTLEAIK 370 380 390 400 410 420 QLQLLEEAQV CHLVEAYKYL RRLENLLQAM ADKQTQTLPD NELEQLALAV AMGYSQWQAL 430 440 450 460 470 480 QNDVQQHMAK VHAVFVTLIG DEEDEVSPVE RHFNELWDMA HNPEVIEQIL QNDLACQNAA 490 500 510 520 530 540 TMSEQIIQFK ADLAKKTLGP RGREVLNRLM PKLFSAIFAD ADAQFGLPRV LHLLHNIATR 550 560 570 580 590 600 TTYLELLDEH PAALTQLVRL CTASPMISEQ LARYPILLDE LIDPQQLYNP IALDAYRTEL 610 620 630 640 650 660 RDFLARIPED DVEQQMDALR QFKQICSLRI AAADIAGVLP VMKVSDHLTY LAEAIVEAVV 670 680 690 700 710 720 HQAWQQVAEK YGEPTHLKDR EGKGFAVVGY GKVGGWELGY NSDLDVVFLH DCPVNVYTDG 730 740 750 760 770 780 KKEIDGRQFY LRLAQRIIHI FSTRTASGIL YEVDTRLRPS GASGLLVCPV DAFEEYQHND 790 800 810 820 830 840 AWTWEHQALV RARMIYGDEH LASEFHRVRH QVLAKPREQA KLQKEVADMR AKMRDHLGGK 850 860 870 880 890 900 KSDRFMLKQD QGGITDIEFL AQYLVLNYSA EKPKLTRWCD NVRIFETLIA QGVMEEAQAM 910 920 930 940 950 LLTQAYTTMR DEIHRRNLLN LDADVALDKF VALRQGVSKA WQEWLESSTI

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000037 Genomic DNA. Translation: BAC93345.1.
RefSeq	NP_933374.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2623349.
GenomeReviews	Gene locus VV0581 in contig BA000037_GR.
KEGG	vvy:VV0581.
NMPDR	fig|196600.1.peg.649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MNY4.
OMA	Q7MNY4. WERYAMI.
Enzyme and pathway databases
BioCyc	VVUL196600:VV0581-MON.
Family and domain databases
HAMAP	MF_00802. [Tree]
InterPro	IPR005190. GlnE. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
Pfam	PF08335. GlnD_UR_UTase. 1 hit. PF03710. GlnE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLNE_VIBVY

Accession

Primary (citable) accession number: Q7MNY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)