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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:VV0611
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalAdd BLAST21
Transmembranei73 – 93HelicalAdd BLAST21
Transmembranei94 – 114HelicalAdd BLAST21
Transmembranei132 – 152HelicalAdd BLAST21
Transmembranei168 – 188HelicalAdd BLAST21
Transmembranei199 – 219HelicalAdd BLAST21
Transmembranei236 – 256HelicalAdd BLAST21
Transmembranei263 – 283HelicalAdd BLAST21
Transmembranei288 – 308HelicalAdd BLAST21
Transmembranei338 – 358HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089261 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MNV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIWLAELLQ PYFSFFRLFE YLSFRAILSV LTALGLSLWM GPRLIKRLQL
60 70 80 90 100
LQIGQVVRNE GPESHFSKRG TPTMGGVMIL AAISITILLW ANLSNPYVWA
110 120 130 140 150
VLAVLMGYGA VGFVDDYRKV VRKNTDGLIA RWKYFWQSAI ALVVAFALYA
160 170 180 190 200
YGKDTAATQL VVPFFKDVMP QLGLMYIVLT YFVIVGTSNA VNLTDGLDGL
210 220 230 240 250
AIMPTVLVAA GFAVIAWATG NVNFSQYLHI PYLPHASELV VVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LALGGALGTI AVLVRQELVL VIMGGVFVME
310 320 330 340 350
TLSVILQVGS YKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISMVLV
360
LIGLATLKVR
Length:360
Mass (Da):39,837
Last modified:December 15, 2003 - v1
Checksum:i8BA2699721BA5C04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC93375.1.
RefSeqiWP_011149501.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC93375; BAC93375; BAC93375.
GeneIDi33955611.
KEGGivvy:VV0611.

Similar proteinsi

Entry informationi

Entry nameiMRAY_VIBVY
AccessioniPrimary (citable) accession number: Q7MNV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 15, 2003
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families