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Protein

Polyphosphate kinase

Gene

ppk

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPUniRule annotation1
Metal bindingi373MagnesiumUniRule annotation1
Metal bindingi403MagnesiumUniRule annotation1
Active sitei433Phosphohistidine intermediateUniRule annotation1
Binding sitei466ATPUniRule annotation1
Binding sitei562ATPUniRule annotation1
Binding sitei590ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:VV0727
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286691 – 700Polyphosphate kinaseAdd BLAST700

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7MNJ0.
SMRiQ7MNJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 462PLD phosphodiesterase 1UniRule annotationAdd BLAST35
Domaini585 – 615PLD phosphodiesterase 2UniRule annotationAdd BLAST31

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000248949.
KOiK00937.
OMAiQIMVANL.
OrthoDBiPOG091H02MN.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiView protein in InterPro
IPR001736. PLipase_D/transphosphatidylase.
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
PfamiView protein in Pfam
PF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
PROSITEiView protein in PROSITE
PS50035. PLD. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7MNJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADKFYIEK ELSWLSFNER VLQEAADKTV PLIERIRFLG IFSNNLDEFY
60 70 80 90 100
KVRFSDVKRR ILINREQGGN DISKHLLSKM QSKALKLNER FDELYNELIR
110 120 130 140 150
DMARRHIFLV NESQLDEAQQ KWIIKYFQKE VLPHITPLML TDEIDVLQFL
160 170 180 190 200
KDEYAYIAVE LKQQEQAKYA LLEIPTDHLP RFIMVPEQKG KRKKTIILLD
210 220 230 240 250
NIIRFCLNDI FRGFFDYDEL NGYAMKMTRD AEYDLRHEVE YSLLEQMSEG
260 270 280 290 300
LSQRLTALPV RFVYERDMPE DMLKYLCYKL KISHYDSLIP GGRYHNFKDF
310 320 330 340 350
IAFPNVGRDY LENKPLPPLA CADFEGYANA FDAIRNQDIL LHYPYHSFEH
360 370 380 390 400
ITELVRQASF DPKVVSIKIN VYRVAKNSRL MNSLIDAVHN GKRVTVVVEL
410 420 430 440 450
QARFDEEANI EWSKRLTDAG VHVIFGVPGM KIHAKLLLIT RREEQGFVRY
460 470 480 490 500
AHIGTGNFHE RTARIYTDFS LLTADQELAA EVRGVFSYIM NPFRPIKFRH
510 520 530 540 550
LIVSPRNSRS QLYRLLDREI HNAQAGKKAS ITLKVNNLVD KGLISKLYAA
560 570 580 590 600
SSAGVKIRMI IRGMCSLVPG LEGISENIEI ISIIDRFLEH PRVLVVHNDG
610 620 630 640 650
DPQVFISSAD WMERNIDNRI EVMSPVRDAR IKQRIIDILS IQFTDTVKAR
660 670 680 690 700
RIDKEMSNNY VERGNRKKIR SQIAIYDYLK NVEKHTRKQK GQVEPNDNNE
Length:700
Mass (Da):81,861
Last modified:December 15, 2003 - v1
Checksum:iA573AED675446DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC93491.1.
RefSeqiWP_011149582.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC93491; BAC93491; BAC93491.
GeneIDi2623504.
KEGGivvy:VV0727.
PATRICifig|196600.6.peg.744.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPK_VIBVY
AccessioniPrimary (citable) accession number: Q7MNJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 15, 2003
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families