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Protein

Polyphosphate kinase

Gene

ppk

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei433 – 4331Phosphohistidine intermediateUniRule annotation
Active sitei452 – 4521Phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-755-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:VV0727
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Polyphosphate kinasePRO_0000128669Add
BLAST

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to histidine residues through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7MNJ0.
SMRiQ7MNJ0. Positions 4-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini428 – 46235PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini585 – 61531PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000248949.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiEOG65TRRG.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase.
InterProiIPR001736. PLipase_D/transphosphatidylase.
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MNJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADKFYIEK ELSWLSFNER VLQEAADKTV PLIERIRFLG IFSNNLDEFY
60 70 80 90 100
KVRFSDVKRR ILINREQGGN DISKHLLSKM QSKALKLNER FDELYNELIR
110 120 130 140 150
DMARRHIFLV NESQLDEAQQ KWIIKYFQKE VLPHITPLML TDEIDVLQFL
160 170 180 190 200
KDEYAYIAVE LKQQEQAKYA LLEIPTDHLP RFIMVPEQKG KRKKTIILLD
210 220 230 240 250
NIIRFCLNDI FRGFFDYDEL NGYAMKMTRD AEYDLRHEVE YSLLEQMSEG
260 270 280 290 300
LSQRLTALPV RFVYERDMPE DMLKYLCYKL KISHYDSLIP GGRYHNFKDF
310 320 330 340 350
IAFPNVGRDY LENKPLPPLA CADFEGYANA FDAIRNQDIL LHYPYHSFEH
360 370 380 390 400
ITELVRQASF DPKVVSIKIN VYRVAKNSRL MNSLIDAVHN GKRVTVVVEL
410 420 430 440 450
QARFDEEANI EWSKRLTDAG VHVIFGVPGM KIHAKLLLIT RREEQGFVRY
460 470 480 490 500
AHIGTGNFHE RTARIYTDFS LLTADQELAA EVRGVFSYIM NPFRPIKFRH
510 520 530 540 550
LIVSPRNSRS QLYRLLDREI HNAQAGKKAS ITLKVNNLVD KGLISKLYAA
560 570 580 590 600
SSAGVKIRMI IRGMCSLVPG LEGISENIEI ISIIDRFLEH PRVLVVHNDG
610 620 630 640 650
DPQVFISSAD WMERNIDNRI EVMSPVRDAR IKQRIIDILS IQFTDTVKAR
660 670 680 690 700
RIDKEMSNNY VERGNRKKIR SQIAIYDYLK NVEKHTRKQK GQVEPNDNNE
Length:700
Mass (Da):81,861
Last modified:December 15, 2003 - v1
Checksum:iA573AED675446DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC93491.1.
RefSeqiWP_011149582.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC93491; BAC93491; BAC93491.
GeneIDi2623504.
KEGGivvy:VV0727.
PATRICi20168264. VBIVibVul40472_0744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC93491.1.
RefSeqiWP_011149582.1. NC_005139.1.

3D structure databases

ProteinModelPortaliQ7MNJ0.
SMRiQ7MNJ0. Positions 4-684.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC93491; BAC93491; BAC93491.
GeneIDi2623504.
KEGGivvy:VV0727.
PATRICi20168264. VBIVibVul40472_0744.

Phylogenomic databases

HOGENOMiHOG000248949.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiEOG65TRRG.

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-755-MONOMER.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase.
InterProiIPR001736. PLipase_D/transphosphatidylase.
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPPK_VIBVY
AccessioniPrimary (citable) accession number: Q7MNJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 15, 2003
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.