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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:VV0745
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001654631 – 350S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST350

Proteomic databases

PRIDEiQ7MNH2

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7MNH2
SMRiQ7MNH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MNH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSDFHFDL PDELIARYPQ SERTASRLLQ LNGNTGAVKD GSFKDVLELV
60 70 80 90 100
QAGDLVVFNN TRVIPARMFG RKESGGKLEV LVERMLDEKR FLAHVRSSKS
110 120 130 140 150
PKPGTLVFLG EEDQYSAEMV ARQDALFELH LKADKTILEV LEEIGHMPLP
160 170 180 190 200
PYIDRPDEDA DKERYQTVYN QKPGAVAAPT AGLHFDNQLL EQIKAKGAEF
210 220 230 240 250
AYVTLHVGAG TFQPVKVDNI LEHHMHSEYA EVPQEVVDAI KATKARGGRV
260 270 280 290 300
IAVGTTSVRS LESAAQESLK NGTELMPFFG DTEIFIFPGY QYQLVDCLIT
310 320 330 340 350
NFHLPESTLI MLVSAFAGYD HTMNAYQHAV ANQYRFFSYG DAMFIEKKTQ
Length:350
Mass (Da):39,206
Last modified:December 15, 2003 - v1
Checksum:iABE863BC4B70479F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA Translation: BAC93509.1
RefSeqiWP_011149594.1, NC_005139.1

Genome annotation databases

EnsemblBacteriaiBAC93509; BAC93509; BAC93509
GeneIDi2623522
KEGGivvy:VV0745

Similar proteinsi

Entry informationi

Entry nameiQUEA_VIBVY
AccessioniPrimary (citable) accession number: Q7MNH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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