Reviewed, UniProtKB/Swiss-Prot Q7MN19 (GLYA1_VIBVY)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 1
      Short name=Serine methylase 1
      Short name=SHMT 1
    EC=2.1.2.1

Gene names

Name:	glyA1
Ordered Locus Names:	VV0898

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00051
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity. HAMAP MF_00051
Subcellular location	Cytoplasm By similarity HAMAP MF_00051.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Serine hydroxymethyltransferase 1 HAMAP MF_00051		PRO_0000113696
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MN19-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 5CE2AC55ACCC464E	FASTA	416	45,332
	10 20 30 40 50 60 MLKRDMNIAD YDAELFAAIQ EETLRQEEHI ELIASENYTS PRVMEAQGSQ LTNKYAEGYP 70 80 90 100 110 120 GKRYYGGCEY VDKAEALAID RACQLFGCEY ANVQPHSGSQ ANSAVYMALL NPGDTVLGMS 130 140 150 160 170 180 LAHGGHLTHG SPVNFSGKHY NVIPYGIDEA GQINYDEMET LALEHKPKMI IGGFSAYSQI 190 200 210 220 230 240 VDWKRMREIA DKVDAYLFVD MAHVAGLIAA GEYPTPVPHA HVVTTTTHKT LAGPRGGLIL 250 260 270 280 290 300 SNAGEDMYKK LNSAVFPGGQ GGPLMHVIAG KAVAFKEAME PEFKAYQARV VKNAKAMVAQ 310 320 330 340 350 360 FQERGYKIVS NGTENHLFLV DLIDKDITGK DADAALGAAN ITVNKNSVPN DPRSPFVTSG 370 380 390 400 410 IRVGTPAITR RGFTEADAKE LANWMCDVLD NIGNEAVIEA TKQKVLEICK RLPVYA

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC93662.1.
RefSeq	NP_933691.1.
3D structure databases
SMR	Q7MN19. Positions 1-416.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MN19.
Genome annotation databases
GeneID	2623676.
GenomeReviews	Gene locus VV0898 in contig BA000037_GR.
KEGG	vvy:VV0898.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0112.
HOGENOM	HBG301263.
OMA	GTSNHLM.
Enzyme and pathway databases
BioCyc	VVUL196600:VV0898-MONOMER.
Family and domain databases
HAMAP	MF_00051_B. SHMT_B. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA1_VIBVY

Accession

Primary (citable) accession number: Q7MN19

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	December 15, 2003
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)