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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Imidazole glycerol phosphate synthase subunit HisH 3 (hisH3), Putative imidazole glycerol phosphate synthase subunit hisF3 (hisF3), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127NADUniRule annotation1
Binding sitei185NADUniRule annotation1
Binding sitei208NADUniRule annotation1
Binding sitei234SubstrateUniRule annotation1
Metal bindingi256ZincUniRule annotation1
Binding sitei256SubstrateUniRule annotation1
Metal bindingi259ZincUniRule annotation1
Binding sitei259SubstrateUniRule annotation1
Active sitei323Proton acceptorUniRule annotation1
Active sitei324Proton acceptorUniRule annotation1
Binding sitei324SubstrateUniRule annotation1
Metal bindingi357ZincUniRule annotation1
Binding sitei357SubstrateUniRule annotation1
Binding sitei411SubstrateUniRule annotation1
Metal bindingi416ZincUniRule annotation1
Binding sitei416SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:VV1351
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358781 – 431Histidinol dehydrogenaseAdd BLAST431

Structurei

3D structure databases

ProteinModelPortaliQ7MLS6
SMRiQ7MLS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MLS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTVVWQSLS ETQQDAILER PAITEGANIT AAVAEVIAKV RAEGDAALFE
60 70 80 90 100
LTEKFDRIKP ESIRVTEQEI EEASARLTAK MKQALEQAYA NIAKFHNAQK
110 120 130 140 150
PTPIKVETQP GVVCEQVTRP IQKVGLYIPG GSAPLPSTVL MLGVPAQIAG
160 170 180 190 200
CRKVVLCSPP PIADEILYVA KLCNIDEVYN VGGGQAVAAM AYGTESVTKV
210 220 230 240 250
DKIFGPGNAY VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DETADADFIA
260 270 280 290 300
ADLLSQAEHG PDSQVVLVTP SVLIADQVTD AVQKQLKQLS RASIAEKALA
310 320 330 340 350
SSLIIIADSL TQAVSISNYY GPEHLIVQTK NPRELLPLLD NAGSIFLGDW
360 370 380 390 400
SPESAGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELSAEGLKNL
410 420 430
APTVVTMAEA EGLDAHKRAV TIRVEKLTAR S
Length:431
Mass (Da):46,069
Last modified:December 15, 2003 - v1
Checksum:i795E4B710E0CAE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA Translation: BAC94115.1
RefSeqiWP_011150020.1, NC_005139.1

Genome annotation databases

EnsemblBacteriaiBAC94115; BAC94115; BAC94115
GeneIDi2624155
KEGGivvy:VV1351
PATRICifig|196600.6.peg.1340

Similar proteinsi

Entry informationi

Entry nameiHISX_VIBVY
AccessioniPrimary (citable) accession number: Q7MLS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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