Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7MKX3

- PYRD_VIBVY

UniProt

Q7MKX3 - PYRD_VIBVY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661SubstrateUniRule annotation
Binding sitei86 – 861FMN; via amide nitrogenUniRule annotation
Binding sitei139 – 1391FMNUniRule annotation
Binding sitei172 – 1721FMNUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Active sitei175 – 1751NucleophileUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei217 – 2171FMNUniRule annotation
Binding sitei245 – 2451FMN; via carbonyl oxygenUniRule annotation
Binding sitei268 – 2681FMN; via amide nitrogenUniRule annotation
Binding sitei297 – 2971FMN; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 665FMNUniRule annotation
Nucleotide bindingi318 – 3192FMNUniRule annotation

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-1711-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
Alternative name(s):
DHOdehaseUniRule annotation
Short name:
DHODUniRule annotation
Short name:
DHODaseUniRule annotation
Dihydroorotate oxidaseUniRule annotation
Gene namesi
Name:pyrDUniRule annotation
Ordered Locus Names:VV1654
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

Subcellular locationi

Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Dihydroorotate dehydrogenase (quinone)PRO_0000148488Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VV1654.

Structurei

3D structure databases

ProteinModelPortaliQ7MKX3.
SMRiQ7MKX3. Positions 1-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1155Substrate bindingUniRule annotation
Regioni246 – 2472Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225103.
KOiK00254.
OMAiGECIDAF.
OrthoDBiEOG65BDN8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MKX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYRLARAGF FQLDAEKAHD LAIQNFKRFT GTPIDLFYRQ QLPNRPVECM
60 70 80 90 100
GLTFRNPVGL AAGLDKNGEC IEAFDAMGFG FVEIGTVTPR AQSGNDKPRL
110 120 130 140 150
FRLVGAEGII NRMGFNNLGV DNLIENVKKA KYSCVLGINI GKNKDTPIEK
160 170 180 190 200
GAEDYLICME KVYEYAGYIA VNISSPNTPG LRTLQYGEAL DELLVELKRK
210 220 230 240 250
QAELEEKHGK YVPLALKIAP DLTDDEISQI CQSLINNKID GVIATNTTLD
260 270 280 290 300
RTMVEGMKYA QEAGGLSGRP LQSRSTEVVR LLRKELQGNI PIIGVGGVDS
310 320 330
YVAAKEKMLA GADLVQVYSG FIYHGPGLVR DIVKNL
Length:336
Mass (Da):36,979
Last modified:December 15, 2003 - v1
Checksum:i8B105A8C1F309AEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94418.1.
RefSeqiNP_934447.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC94418; BAC94418; BAC94418.
GeneIDi2624460.
KEGGivvy:VV1654.
PATRICi20170094. VBIVibVul40472_1632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94418.1 .
RefSeqi NP_934447.1. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MKX3.
SMRi Q7MKX3. Positions 1-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV1654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC94418 ; BAC94418 ; BAC94418 .
GeneIDi 2624460.
KEGGi vvy:VV1654.
PATRICi 20170094. VBIVibVul40472_1632.

Phylogenomic databases

eggNOGi COG0167.
HOGENOMi HOG000225103.
KOi K00254.
OMAi GECIDAF.
OrthoDBi EOG65BDN8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci VVUL196600:GJ9W-1711-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPYRD_VIBVY
AccessioniPrimary (citable) accession number: Q7MKX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3