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Q7MKX3

- PYRD_VIBVY

UniProt

Q7MKX3 - PYRD_VIBVY

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Protein
Dihydroorotate dehydrogenase (quinone)
Gene
pyrD, VV1654
Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarity
Binding sitei86 – 861FMN; via amide nitrogen By similarity
Binding sitei139 – 1391FMN By similarity
Binding sitei172 – 1721FMN By similarity
Binding sitei172 – 1721Substrate By similarity
Active sitei175 – 1751Nucleophile By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei217 – 2171FMN By similarity
Binding sitei245 – 2451FMN; via carbonyl oxygen By similarity
Binding sitei268 – 2681FMN; via amide nitrogen By similarity
Binding sitei297 – 2971FMN; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 665FMN By similarity
Nucleotide bindingi318 – 3192FMN By similarity

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-1711-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone) (EC:1.3.5.2)
Alternative name(s):
DHOdehase
Short name:
DHOD
Short name:
DHODase
Dihydroorotate oxidase
Gene namesi
Name:pyrD
Ordered Locus Names:VV1654
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Dihydroorotate dehydrogenase (quinone)UniRule annotation
PRO_0000148488Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196600.VV1654.

Structurei

3D structure databases

ProteinModelPortaliQ7MKX3.
SMRiQ7MKX3. Positions 1-336.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1155Substrate binding By similarity
Regioni246 – 2472Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225103.
KOiK00254.
OMAiGECIDAF.
OrthoDBiEOG65BDN8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MKX3-1 [UniParc]FASTAAdd to Basket

« Hide

MLYRLARAGF FQLDAEKAHD LAIQNFKRFT GTPIDLFYRQ QLPNRPVECM    50
GLTFRNPVGL AAGLDKNGEC IEAFDAMGFG FVEIGTVTPR AQSGNDKPRL 100
FRLVGAEGII NRMGFNNLGV DNLIENVKKA KYSCVLGINI GKNKDTPIEK 150
GAEDYLICME KVYEYAGYIA VNISSPNTPG LRTLQYGEAL DELLVELKRK 200
QAELEEKHGK YVPLALKIAP DLTDDEISQI CQSLINNKID GVIATNTTLD 250
RTMVEGMKYA QEAGGLSGRP LQSRSTEVVR LLRKELQGNI PIIGVGGVDS 300
YVAAKEKMLA GADLVQVYSG FIYHGPGLVR DIVKNL 336
Length:336
Mass (Da):36,979
Last modified:December 15, 2003 - v1
Checksum:i8B105A8C1F309AEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC94418.1.
RefSeqiNP_934447.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC94418; BAC94418; BAC94418.
GeneIDi2624460.
KEGGivvy:VV1654.
PATRICi20170094. VBIVibVul40472_1632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC94418.1 .
RefSeqi NP_934447.1. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MKX3.
SMRi Q7MKX3. Positions 1-336.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196600.VV1654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC94418 ; BAC94418 ; BAC94418 .
GeneIDi 2624460.
KEGGi vvy:VV1654.
PATRICi 20170094. VBIVibVul40472_1632.

Phylogenomic databases

eggNOGi COG0167.
HOGENOMi HOG000225103.
KOi K00254.
OMAi GECIDAF.
OrthoDBi EOG65BDN8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci VVUL196600:GJ9W-1711-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPYRD_VIBVY
AccessioniPrimary (citable) accession number: Q7MKX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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