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Q7MKQ9

- NAGK_VIBVY

UniProt

Q7MKQ9 - NAGK_VIBVY

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-1776-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:VV1719
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000270123Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VV1719.

Structurei

3D structure databases

ProteinModelPortaliQ7MKQ9.
SMRiQ7MKQ9. Positions 1-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiATFQLAN.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7MKQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGFDVGGT KIEFGAFNEK LERVATERVP TPTDDYPLLL ETIAGLVAKY
60 70 80 90 100
DQEFACEGKI GLGLPGMEDA DDATVLTVNV PAAKGKPLRA DLEAKIGRSV
110 120 130 140 150
KIENDANCFA LSEAWDEELQ DAPSVMGLIL GTGFGGGLIY EGKVFSGRNN
160 170 180 190 200
VAGELGHMRL PLDAWFHLGD NAPLLGCGCG KKGCLDSYLS GRGFELLYAH
210 220 230 240 250
YYGEEKKAID IIKANAAGDE KAAEHVERFM ELLAICFGNI FTANDPHVVA
260 270 280 290 300
LGGGLSNFEL IYEEMPKRVP KYLLSVAKCP KIIKAKHGDS GGVRGAAFLN

IKG
Length:303
Mass (Da):32,570
Last modified:January 9, 2007 - v2
Checksum:iF1804F008B123B61
GO

Sequence cautioni

The sequence BAC94483.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC94483.1. Different initiation.
RefSeqiNP_934512.2. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC94483; BAC94483; BAC94483.
GeneIDi2624525.
KEGGivvy:VV1719.
PATRICi20170218. VBIVibVul40472_1694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000037 Genomic DNA. Translation: BAC94483.1 . Different initiation.
RefSeqi NP_934512.2. NC_005139.1.

3D structure databases

ProteinModelPortali Q7MKQ9.
SMRi Q7MKQ9. Positions 1-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196600.VV1719.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC94483 ; BAC94483 ; BAC94483 .
GeneIDi 2624525.
KEGGi vvy:VV1719.
PATRICi 20170218. VBIVibVul40472_1694.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OMAi ATFQLAN.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci VVUL196600:GJ9W-1776-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiNAGK_VIBVY
AccessioniPrimary (citable) accession number: Q7MKQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 1, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3