Reviewed, UniProtKB/Swiss-Prot Q7MK46 (TPMT_VIBVY)

Names and origin

Protein names

Recommended name:
    Thiopurine S-methyltransferase
    EC=2.1.1.67
Alternative name(s):
    Thiopurine methyltransferase

Gene names

Name:	tpm
Ordered Locus Names:	VV1964

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Thiopurine S-methyltransferase HAMAP MF_00812		PRO_0000220137
Sites
	Binding site	11	1	S-adenosyl-L-methionine By similarity
	Binding site	46	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	67	1	S-adenosyl-L-methionine By similarity
	Binding site	122	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7MK46-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 41DCFED98D43B5B9	FASTA	217	24,868
	10 20 30 40 50 60 MRDAEFWHNK WASNQIGFHL EDVNPLLTRF WSALAPKREE TVLVPLCGKT EDLAWLATKH 70 80 90 100 110 120 DHVEGAELSL IAVRSFFAEH FYTPTVTPIS GQHELYQFDE LSIYAGDFFT APLSKADLIY 130 140 150 160 170 180 DRAALIALPE EMRVEYVQRI RGLLNPGGRI LLVSLDYPQQ EMAGPPFSVT QEEIEHLFAG 190 200 210 MHVTRLYQDI ADEHHPKIAK QGLSRFSEEV YVIENDK

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000037 Genomic DNA. Translation: BAC94728.1.
RefSeq	NP_934757.1.
3D structure databases
HSSP	HSSP built from PDB template 1PJZ based on UniProtKB O86262.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MK46.
Genome annotation databases
GeneID	2624770.
GenomeReviews	Gene locus VV1964 in contig BA000037_GR.
KEGG	vvy:VV1964.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7MK46.
OMA	PPFAVSP.
Enzyme and pathway databases
BioCyc	VVUL196600:VV1964-MON.
Family and domain databases
HAMAP	MF_00812. [Tree]
InterPro	IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPMT_VIBVY

Accession

Primary (citable) accession number: Q7MK46

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 15, 2003
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)