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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-2026-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:VV1969
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Nicotinate phosphoribosyltransferasePRO_0000205850Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196600.VV1969.

Structurei

3D structure databases

ProteinModelPortaliQ7MK41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MK41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAPLFQPAI IQSVLDLDVY KINMMQAAYR FYPQTQVRYE LIVRSDDNLS
60 70 80 90 100
DLVEEVREEI NRLAELRFDA AQLAYLAEKA PYLTAEFLSY LETFRFHPQQ
110 120 130 140 150
QVSVGIFRTA QGDCQLRVTI NGIWHETILY ETLVMSIISE LRNRRYWAQI
160 170 180 190 200
PQSQLHKVLE DKLDFLDSEL KRRNITNFRF SEMGTRRRFS FAAQKTMLDV
210 220 230 240 250
LRARVPELLL GTSNYHLAQE FNLTPIGTVA HEWTMAHQAL VAVQHSQCVA
260 270 280 290 300
LDKWLEAFNG SLGIALTDTI GIDAFLSDFD LEKATAYAGV RHDSGSPFVW
310 320 330 340 350
GDKIIAHYES LGIDPSTKTL IFTDGLDFAR ALDICEYFAG RAQISFGIGT
360 370 380 390 400
FLANDMGNWT NDKGIRYQPI SMVVKMAECN GSPVAKISDE PEKAMCEDIF
410 420 430
FLMNLKQRFG LEVDLDKAIE TLKQMKRQQK KRIQSVA
Length:437
Mass (Da):49,946
Last modified:December 15, 2003 - v1
Checksum:i572E30CE2BA4FC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94733.1.
RefSeqiNP_934762.1. NC_005139.1.
WP_011150519.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC94733; BAC94733; BAC94733.
GeneIDi2624775.
KEGGivvy:VV1969.
PATRICi20170824. VBIVibVul40472_1997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94733.1.
RefSeqiNP_934762.1. NC_005139.1.
WP_011150519.1. NC_005139.1.

3D structure databases

ProteinModelPortaliQ7MK41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196600.VV1969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC94733; BAC94733; BAC94733.
GeneIDi2624775.
KEGGivvy:VV1969.
PATRICi20170824. VBIVibVul40472_1997.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciVVUL196600:GJ9W-2026-MONOMER.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiPNCB_VIBVY
AccessioniPrimary (citable) accession number: Q7MK41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 15, 2003
Last modified: March 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.