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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:VV1969
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058501 – 437Nicotinate phosphoribosyltransferaseAdd BLAST437

Structurei

3D structure databases

ProteinModelPortaliQ7MK41
SMRiQ7MK41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q7MK41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAPLFQPAI IQSVLDLDVY KINMMQAAYR FYPQTQVRYE LIVRSDDNLS
60 70 80 90 100
DLVEEVREEI NRLAELRFDA AQLAYLAEKA PYLTAEFLSY LETFRFHPQQ
110 120 130 140 150
QVSVGIFRTA QGDCQLRVTI NGIWHETILY ETLVMSIISE LRNRRYWAQI
160 170 180 190 200
PQSQLHKVLE DKLDFLDSEL KRRNITNFRF SEMGTRRRFS FAAQKTMLDV
210 220 230 240 250
LRARVPELLL GTSNYHLAQE FNLTPIGTVA HEWTMAHQAL VAVQHSQCVA
260 270 280 290 300
LDKWLEAFNG SLGIALTDTI GIDAFLSDFD LEKATAYAGV RHDSGSPFVW
310 320 330 340 350
GDKIIAHYES LGIDPSTKTL IFTDGLDFAR ALDICEYFAG RAQISFGIGT
360 370 380 390 400
FLANDMGNWT NDKGIRYQPI SMVVKMAECN GSPVAKISDE PEKAMCEDIF
410 420 430
FLMNLKQRFG LEVDLDKAIE TLKQMKRQQK KRIQSVA
Length:437
Mass (Da):49,946
Last modified:December 15, 2003 - v1
Checksum:i572E30CE2BA4FC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA Translation: BAC94733.1
RefSeqiWP_011150519.1, NC_005139.1

Genome annotation databases

EnsemblBacteriaiBAC94733; BAC94733; BAC94733
GeneIDi2624775
KEGGivvy:VV1969
PATRICifig|196600.6.peg.1997

Similar proteinsi

Entry informationi

Entry nameiPNCB_VIBVY
AccessioniPrimary (citable) accession number: Q7MK41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 15, 2003
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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