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Q7MK24 (SPEA_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:VV1986
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149986

Regions

Region290 – 30011Substrate-binding Potential

Amino acid modifications

Modified residue1051N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

..................................................................................................... 640
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7MK24 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 3157EA5825FFF912

FASTA64072,493
        10         20         30         40         50         60 
MRLDVEQTSK LDRVRADYNV HYWSQGFYGI DDQGEMYVSP RSDNAHQIQL SKIVKQLEER 

        70         80         90        100        110        120 
QLNVPVLVRF PQILHQRVHS ICDAFNQAIE EYQYPNKYLL VYPIKVNQQR EVVDEILASQ 

       130        140        150        160        170        180 
AQLETKQLGL EAGSKPELLA VLAMAQHASS VIVCNGYKDR EYIRLALIGE KLGHKVFIVL 

       190        200        210        220        230        240 
EKMSELDLVL REAKSLGVTP RLGIRIRLAS QGAGKWQASG GEKSKFGLSA SQVLNVISRL 

       250        260        270        280        290        300 
KKENQLDTLQ LVHFHLGSQM ANIRDVRNGV NESARFYCEL RTLGANITYF DVGGGLAIDY 

       310        320        330        340        350        360 
DGTRSQSSNS MNYGLVEYAR NIVNTVGDVC KDYKQPMPVI ISESGRSLTA HHAVLISNVI 

       370        380        390        400        410        420 
GTETYKPETV TEPEEDFPLL LNNMWRSWLN LHNGTDARAL IEIYNDTQSD LAEVHSQFAT 

       430        440        450        460        470        480 
GVLTLEHRAW AEQTSLRIYY ELNRLMSTKN RFHRPILDEL SERLADKFFV NFSLFQSLPD 

       490        500        510        520        530        540 
SWGIDQVFPV LPLSGLQNAA DRRAVMLDIT CDSDGAIDAY VDGQGIESTL PVPAWNEDEP 

       550        560        570        580        590        600 
YLMGFFLVGA YQEILGDMHN LFGDTHSVVV NVGDQGEINI DFINEGDTVE DMMRYVHIDV 

       610        620        630        640 
DQIRKNYHSL VSQRVDQEEQ QQILAELEQG LSGYTYLEDF 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000037 Genomic DNA. Translation: BAC94750.1.
RefSeqNP_934779.1. NC_005139.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3N2OX-ray2.30A/B/C/D1-640[»]
ProteinModelPortalQ7MK24.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VV1986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC94750; BAC94750; BAC94750.
GeneID2624792.
KEGGvvy:VV1986.
PATRIC20170858. VBIVibVul40472_2014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-2043-MONOMER.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ7MK24.

Entry information

Entry nameSPEA_VIBVY
AccessionPrimary (citable) accession number: Q7MK24
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references