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Q7MJI2 (FUCI_VIBVY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:VV2179
OrganismVibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]
Taxonomic identifier196600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582L-fucose isomerase HAMAP-Rule MF_01254
PRO_0000204154

Sites

Active site3331Proton acceptor By similarity
Active site3571Proton acceptor By similarity
Metal binding3331Manganese By similarity
Metal binding3571Manganese By similarity
Metal binding5201Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7MJI2 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 96F9E99608057E52

FASTA58264,482
        10         20         30         40         50         60 
MSNLVKIGIR PTIDGRRLGV RESLEEQTMN MAKNLANFIA ENVRHVSGDA VECVIADSTI 

        70         80         90        100        110        120 
GGVAEAAACA DKFKRENVGL SITVTPCWCY GTETIDMDPH MPKAIWGFNG TERPGAVYLA 

       130        140        150        160        170        180 
AAMAGHSQVG LPAFSIYGEE VQDKDDTSIP SDVQEKILRF CRAGLTVATI RGKSYLSMGS 

       190        200        210        220        230        240 
VSMGIAGSIV DQPFFQHYLG MRNEYVDMTE IKRRLDREIF DKEEFELAMA WTKEHCHEGK 

       250        260        270        280        290        300 
DYNREPMSEA RKQEDWQTVV KMTMIMRDLM EGNPKLAEMG FGEEALGHNA VVGGFQGQRH 

       310        320        330        340        350        360 
WTDHLPNGDF SEAILNSSFD WNGIREPFVI ATENDSLNGV NMLFGKMLTG QAQVFCDVRT 

       370        380        390        400        410        420 
YWSADSVERV SGYRPESGFI HLVNSGSAAL DGCGEAKLTS GESAIKPHWQ MSAQDAEACL 

       430        440        450        460        470        480 
SATKWPPADV EYFRGGGFSS NFLTHGGMPF TMHRINIIKG IGPVLQIAEG HSITLPQEVH 

       490        500        510        520        530        540 
ETLNERTNPT WPTTWFVPRL NDEGAFKDVY SVMANWGANH CVITYGHVGA DLITLASMLR 

       550        560        570        580 
IPVAMHNVEE SDVFRPHTWS AFGQDKEGQD YRACATFGPL YK 

« Hide

References

[1]"Comparative genome analysis of Vibrio vulnificus, a marine pathogen."
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.
Genome Res. 13:2577-2587(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YJ016.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000037 Genomic DNA. Translation: BAC94943.1.
RefSeqNP_934972.1. NC_005139.1.

3D structure databases

ProteinModelPortalQ7MJI2.
SMRQ7MJI2. Positions 3-582.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196600.VV2179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC94943; BAC94943; BAC94943.
GeneID2624985.
KEGGvvy:VV2179.
PATRIC20171222. VBIVibVul40472_2196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2407.
HOGENOMHOG000249674.
KOK01818.
OMAKIGIRPT.
OrthoDBEOG6FJNCF.
ProtClustDBPRK10991.

Enzyme and pathway databases

BioCycVVUL196600:GJ9W-2236-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_VIBVY
AccessionPrimary (citable) accession number: Q7MJI2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways