Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-fucose isomerase

Gene

fucI

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathway: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei333 – 3331Proton acceptorUniRule annotation
Metal bindingi333 – 3331ManganeseUniRule annotation
Active sitei357 – 3571Proton acceptorUniRule annotation
Metal bindingi357 – 3571ManganeseUniRule annotation
Metal bindingi520 – 5201ManganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-2236-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:VV2179
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002675 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582L-fucose isomerasePRO_0000204154Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7MJI2.
SMRiQ7MJI2. Positions 3-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MJI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLVKIGIR PTIDGRRLGV RESLEEQTMN MAKNLANFIA ENVRHVSGDA
60 70 80 90 100
VECVIADSTI GGVAEAAACA DKFKRENVGL SITVTPCWCY GTETIDMDPH
110 120 130 140 150
MPKAIWGFNG TERPGAVYLA AAMAGHSQVG LPAFSIYGEE VQDKDDTSIP
160 170 180 190 200
SDVQEKILRF CRAGLTVATI RGKSYLSMGS VSMGIAGSIV DQPFFQHYLG
210 220 230 240 250
MRNEYVDMTE IKRRLDREIF DKEEFELAMA WTKEHCHEGK DYNREPMSEA
260 270 280 290 300
RKQEDWQTVV KMTMIMRDLM EGNPKLAEMG FGEEALGHNA VVGGFQGQRH
310 320 330 340 350
WTDHLPNGDF SEAILNSSFD WNGIREPFVI ATENDSLNGV NMLFGKMLTG
360 370 380 390 400
QAQVFCDVRT YWSADSVERV SGYRPESGFI HLVNSGSAAL DGCGEAKLTS
410 420 430 440 450
GESAIKPHWQ MSAQDAEACL SATKWPPADV EYFRGGGFSS NFLTHGGMPF
460 470 480 490 500
TMHRINIIKG IGPVLQIAEG HSITLPQEVH ETLNERTNPT WPTTWFVPRL
510 520 530 540 550
NDEGAFKDVY SVMANWGANH CVITYGHVGA DLITLASMLR IPVAMHNVEE
560 570 580
SDVFRPHTWS AFGQDKEGQD YRACATFGPL YK
Length:582
Mass (Da):64,482
Last modified:December 15, 2003 - v1
Checksum:i96F9E99608057E52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94943.1.
RefSeqiNP_934972.1. NC_005139.1.
WP_011150692.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC94943; BAC94943; BAC94943.
GeneIDi2624985.
KEGGivvy:VV2179.
PATRICi20171222. VBIVibVul40472_2196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC94943.1.
RefSeqiNP_934972.1. NC_005139.1.
WP_011150692.1. NC_005139.1.

3D structure databases

ProteinModelPortaliQ7MJI2.
SMRiQ7MJI2. Positions 3-582.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC94943; BAC94943; BAC94943.
GeneIDi2624985.
KEGGivvy:VV2179.
PATRICi20171222. VBIVibVul40472_2196.

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiRTDPTWP.
OrthoDBiEOG6FJNCF.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.
BioCyciVVUL196600:GJ9W-2236-MONOMER.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YJ016.

Entry informationi

Entry nameiFUCI_VIBVY
AccessioniPrimary (citable) accession number: Q7MJI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.