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Q7MIH2

- LPXB_VIBVY

UniProt

Q7MIH2 - LPXB_VIBVY

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciVVUL196600:GJ9W-2603-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:VV2544
    OrganismiVibrio vulnificus (strain YJ016)
    Taxonomic identifieri196600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002675: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000190191Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196600.VV2544.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7MIH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7MIH2-1 [UniParc]FASTAAdd to Basket

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    MSNKPLRIGI VAGELSGDTL GEGFIKAIKA VHPDAEFVGI GGPKMIALGC    50
    QSLFDMEELA VMGLVEVLGR LPRLLKVKAE LVRYFTENPP DVFVGIDAPD 100
    FNLRLELDLK NAGIKTVHYV SPSVWAWRQK RIFKIAKATH LVLAFLPFEK 150
    AFYDKFNVPC EFIGHTLADA IPLESDKAPA RELLGLEQDK QWLAVLPGSR 200
    GSELKMLSQP FIETCKKLQQ AFPELGFVVA LVNQKRREQF EQAWKEYAPE 250
    LDFKLVDDTA RNVITASDAV MLASGTVALE CMLLKRPMVV GYRVNAVTAF 300
    LAKRLLKTQY VSLPNILADT ELVKEYLQDD CTPDNLFGEV SRLLEGDNHQ 350
    MLDKFTEMHH WIRKDADQQA ANAVLKLIEK 380
    Length:380
    Mass (Da):42,610
    Last modified:December 15, 2003 - v1
    Checksum:iFCF052209B276171
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000037 Genomic DNA. Translation: BAC95308.1.
    RefSeqiNP_935337.1. NC_005139.1.
    WP_011079775.1. NC_005139.1.

    Genome annotation databases

    EnsemblBacteriaiBAC95308; BAC95308; BAC95308.
    GeneIDi2625352.
    KEGGivvy:VV2544.
    PATRICi20171930. VBIVibVul40472_2548.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000037 Genomic DNA. Translation: BAC95308.1 .
    RefSeqi NP_935337.1. NC_005139.1.
    WP_011079775.1. NC_005139.1.

    3D structure databases

    ProteinModelPortali Q7MIH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196600.VV2544.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC95308 ; BAC95308 ; BAC95308 .
    GeneIDi 2625352.
    KEGGi vvy:VV2544.
    PATRICi 20171930. VBIVibVul40472_2548.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci VVUL196600:GJ9W-2603-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YJ016.

    Entry informationi

    Entry nameiLPXB_VIBVY
    AccessioniPrimary (citable) accession number: Q7MIH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3