Reviewed, UniProtKB/Swiss-Prot Q7MIA6 (ARGA_VIBVY)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	VV2611

Organism

Vibrio vulnificus (strain YJ016) [Complete proteome] [HAMAP]

Taxonomic identifier

196600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm Probable HAMAP MF_01105.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186811
Regions
	Domain	299 – 438	140	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q7MIA6-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: AA9638D7FC647E2B	FASTA	445	49,033
	10 20 30 40 50 60 MKIRSTALVK GFRQSTPYVN AHRGKTMVIL LGGEAIADKN FSNIINDIAL MHSLGVKVVL 70 80 90 100 110 120 VYGARPQINQ LLDKQSSQTP YHKHIRVTDE NSLSIVMQAA GQLQLAITAS LSMSLNNTPM 130 140 150 160 170 180 AGTHLNVVSG NFVIAQPLGI DEGVDYCHSG RIRRIDTEAI NRSLDQGSIV LLGPIASSVT 190 200 210 220 230 240 GECFNLLSEE VATQVAIKLK ADKLIGFCSE QGVIDEEGNA VAELFPSDAE KFIQKLSVDV 250 260 270 280 290 300 DPDSDFHSGT LRFLKGAVAA CRAGVPRSHL ISYKIDGALI QELFSFDGIG TQVVMASAEQ 310 320 330 340 350 360 VRQACIDDIG GILELIRPLE EQGILVRRSR EQLEQEVERF TIIEKDGLII GCAALYPYID 370 380 390 400 410 420 EHMAEMACVA IHPDYRDGNR GLLLLNYMKH RSKSIGIEQI FVLTTHSVHW FREQGFYEIG 430 440 VDSLPMAKKS LYNYQRRSKI LALPL

References

[1]

"Comparative genome analysis of Vibrio vulnificus, a marine pathogen." Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F. Genome Res. 13:2577-2587(2003) [PubMed: 14656965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000037 Genomic DNA. Translation: BAC95375.1.
RefSeq	NP_935404.1.
3D structure databases
SMR	Q7MIA6. Positions 3-294, 7-445.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7MIA6.
Genome annotation databases
GeneID	2625419.
GenomeReviews	Gene locus VV2611 in contig BA000037_GR.
KEGG	vvy:VV2611.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG545264.
OMA	APYIHAF.
Enzyme and pathway databases
BioCyc	VVUL196600:VV2611-MONOMER.
Family and domain databases
HAMAP	MF_01105. N-acetyl_glu_synth. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_VIBVY

Accession

Primary (citable) accession number: Q7MIA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	December 15, 2003
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)