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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Substrate
Active sitei103 – 1031Proton acceptorUniRule annotation
Binding sitei121 – 1211Substrate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciVVUL196600:GJ9W-2919-MONOMER.
BRENDAi5.3.1.6. 7786.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:VV2850
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Ribose-5-phosphate isomerase APRO_0000158494Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 138Combined sources
Helixi14 – 174Combined sources
Beta strandi23 – 264Combined sources
Helixi30 – 4011Combined sources
Helixi41 – 455Combined sources
Beta strandi48 – 525Combined sources
Helixi54 – 629Combined sources
Helixi70 – 723Combined sources
Beta strandi76 – 816Combined sources
Beta strandi84 – 863Combined sources
Beta strandi96 – 983Combined sources
Helixi100 – 10910Combined sources
Beta strandi110 – 1178Combined sources
Beta strandi124 – 1263Combined sources
Beta strandi131 – 1355Combined sources
Helixi137 – 1393Combined sources
Helixi140 – 14910Combined sources
Beta strandi153 – 1564Combined sources
Beta strandi167 – 1737Combined sources
Helixi179 – 1879Combined sources
Beta strandi192 – 1987Combined sources
Beta strandi204 – 2085Combined sources
Beta strandi211 – 2133Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ENQX-ray2.00A/B1-218[»]
3ENVX-ray2.00A/B1-218[»]
3ENWX-ray2.00A/B1-218[»]
ProteinModelPortaliQ7MHL9.
SMRiQ7MHL9. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7MHL9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 314Substrate bindingCurated
Regioni81 – 844Substrate bindingCurated
Regioni94 – 974Substrate bindingCurated

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MHL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDEMKKAA GWAALKYVEK GSIVGVGTGS TVNHFIDALG TMSEEIKGAV
60 70 80 90 100
SSSVASTEKL EALGIKIFDC NEVASLDIYV DGADEINADR EMIKGGGAAL
110 120 130 140 150
TREKIVAAIA DKFICIVDGT KAVDVLGTFP LPVEVIPMAR SYVARQLVKL
160 170 180 190 200
GGDPCYREGV ITDNGNVILD VYGMKITNPK QLEDQINAIP GVVTVGLFAH
210
RGADVVITGT PEGAKIEE
Length:218
Mass (Da):22,985
Last modified:January 16, 2004 - v2
Checksum:iB5915E8097F52511
GO

Sequence cautioni

The sequence BAC95614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95614.1. Different initiation.
RefSeqiWP_043877321.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95614; BAC95614; BAC95614.
GeneIDi2625668.
KEGGivvy:VV2850.
PATRICi20172530. VBIVibVul40472_2838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95614.1. Different initiation.
RefSeqiWP_043877321.1. NC_005139.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ENQX-ray2.00A/B1-218[»]
3ENVX-ray2.00A/B1-218[»]
3ENWX-ray2.00A/B1-218[»]
ProteinModelPortaliQ7MHL9.
SMRiQ7MHL9. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC95614; BAC95614; BAC95614.
GeneIDi2625668.
KEGGivvy:VV2850.
PATRICi20172530. VBIVibVul40472_2838.

Phylogenomic databases

HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciVVUL196600:GJ9W-2919-MONOMER.
BRENDAi5.3.1.6. 7786.

Miscellaneous databases

EvolutionaryTraceiQ7MHL9.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_VIBVY
AccessioniPrimary (citable) accession number: Q7MHL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.