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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Vibrio vulnificus (strain YJ016)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7Substrate1
Active sitei103Proton acceptorUniRule annotation1
Binding sitei121Substrate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.3.1.6. 7786.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:VV2850
OrganismiVibrio vulnificus (strain YJ016)
Taxonomic identifieri196600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002675 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001584941 – 218Ribose-5-phosphate isomerase AAdd BLAST218

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Helixi14 – 17Combined sources4
Beta strandi23 – 26Combined sources4
Helixi30 – 40Combined sources11
Helixi41 – 45Combined sources5
Beta strandi48 – 52Combined sources5
Helixi54 – 62Combined sources9
Helixi70 – 72Combined sources3
Beta strandi76 – 81Combined sources6
Beta strandi84 – 86Combined sources3
Beta strandi96 – 98Combined sources3
Helixi100 – 109Combined sources10
Beta strandi110 – 117Combined sources8
Beta strandi124 – 126Combined sources3
Beta strandi131 – 135Combined sources5
Helixi137 – 139Combined sources3
Helixi140 – 149Combined sources10
Beta strandi153 – 156Combined sources4
Beta strandi167 – 173Combined sources7
Helixi179 – 187Combined sources9
Beta strandi192 – 198Combined sources7
Beta strandi204 – 208Combined sources5
Beta strandi211 – 213Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ENQX-ray2.00A/B1-218[»]
3ENVX-ray2.00A/B1-218[»]
3ENWX-ray2.00A/B1-218[»]
ProteinModelPortaliQ7MHL9.
SMRiQ7MHL9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7MHL9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate bindingCurated4
Regioni81 – 84Substrate bindingCurated4
Regioni94 – 97Substrate bindingCurated4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7MHL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDEMKKAA GWAALKYVEK GSIVGVGTGS TVNHFIDALG TMSEEIKGAV
60 70 80 90 100
SSSVASTEKL EALGIKIFDC NEVASLDIYV DGADEINADR EMIKGGGAAL
110 120 130 140 150
TREKIVAAIA DKFICIVDGT KAVDVLGTFP LPVEVIPMAR SYVARQLVKL
160 170 180 190 200
GGDPCYREGV ITDNGNVILD VYGMKITNPK QLEDQINAIP GVVTVGLFAH
210
RGADVVITGT PEGAKIEE
Length:218
Mass (Da):22,985
Last modified:January 16, 2004 - v2
Checksum:iB5915E8097F52511
GO

Sequence cautioni

The sequence BAC95614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95614.1. Different initiation.
RefSeqiWP_043877321.1. NC_005139.1.

Genome annotation databases

EnsemblBacteriaiBAC95614; BAC95614; BAC95614.
GeneIDi2625668.
KEGGivvy:VV2850.
PATRICi20172530. VBIVibVul40472_2838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000037 Genomic DNA. Translation: BAC95614.1. Different initiation.
RefSeqiWP_043877321.1. NC_005139.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ENQX-ray2.00A/B1-218[»]
3ENVX-ray2.00A/B1-218[»]
3ENWX-ray2.00A/B1-218[»]
ProteinModelPortaliQ7MHL9.
SMRiQ7MHL9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC95614; BAC95614; BAC95614.
GeneIDi2625668.
KEGGivvy:VV2850.
PATRICi20172530. VBIVibVul40472_2838.

Phylogenomic databases

HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BRENDAi5.3.1.6. 7786.

Miscellaneous databases

EvolutionaryTraceiQ7MHL9.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_VIBVY
AccessioniPrimary (citable) accession number: Q7MHL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.